Introduction: Febrile neutropenia (FN) is a potential life-threatening complication of myelosuppressive chemotherapy, particularly when induced by infection. There is evidence that FN can originate from the oral cavity, but its contribution to FN is largely understudied in patients treated for solid tumors. The aim of this study was to assess the prevalence of FN in these patients and to evaluate its relation with dental foci and oral mucositis.
Material And Methods: A prospective longitudinal observational study was conducted. Patients diagnosed with solid tumors and lymphoma scheduled to be treated with myelosuppressive chemotherapy with an intermediate risk of developing FN were included. A pre-chemotherapy dental examination was performed and patients were followed during and after chemotherapy regimen. During subsequent hospital visits for chemotherapy administration, the oral cavity was inspected and oral mucositis (OM) was scored using the CTC-AE version 3.0. When patients presented with fever, a comprehensive full body examination including laboratory/microbiological/imaging investigation was performed.
Results: Eighty-eight patients were included. Pre-chemotherapy, 39 patients (44.3%) were diagnosed with a dental focus. During chemotherapy, 46 patients developed OM (53.4%), of which 15 patients had a maximum score of grade II (ulcerative mucositis). Ten patients developed FN during the follow-up period. Patients with FN more often suffered from ulcerative OM compared to patients without FN; both FN and mucositis risk was associated with the myelotoxicity of chemotherapy. However, no relation could be established between the presence of dental foci prior to chemotherapy and the development of FN ( > 0.05).
Conclusion: A significant relation was identified between ulcerative OM and FN, but no robust conclusions could be drawn with respect to a relationship between the presence of dental foci and FN.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280026 | PMC |
| http://dx.doi.org/10.3389/froh.2022.940044 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mapping the Research Landscape on temporomandibular disorders and orthodontics treatment: A Bibliometric Analysis.
J Stomatol Oral Maxillofac Surg
January 2025
Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Background: Temporomandibular disorders (TMD) and orthodontic treatment are significant areas within dental and maxillofacial research. However, comprehensive bibliometric analyses highlighting global trends and collaboration networks are lacking.
Objective(s): This study aims to systematically map the publication landscape, identify prevailing research trends, highlight influential authors and institutions, and illuminate emerging topics in TMD and orthodontic research.
Elimination of oral foci of infection might lead to clinical improvement of Graves' orbitopathy.
Graefes Arch Clin Exp Ophthalmol
January 2025
Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland.
Purpose: Graves' disease (GD) and Graves' orbitopathy (GO) are multifactorial disorders with links to the gut microbiome and autoimmunity. It is observed that patients with GD exhibit altered gut microbiome diversity. However, little is known about the role of oral microbiota in GD and GO.
View Article and Find Full Text PDFMultiple Bilateral Parotid Calcifications in a Patient with Sjögren's Syndrome: A Case Report.
J Dent (Shiraz)
December 2024
Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
This study investigates the calcifications in the parotid glands of a patient with Sjögren's syndrome (SS). A 52-year-old female patient presented for a routine dental examination who found to have multiple radiopacities in both parotid glands on panoramic radiograph. Further evaluation revealed swelling and tenderness in the parotid glands, decayed teeth, and dryness of the mouth and eyes.
View Article and Find Full Text PDFPatients with severe odontogenic infections receive insufficient dental treatment before hospitalization - a retrospective cross-sectional study.
Acta Odontol Scand
December 2024
Section of Oral Biology and Immunopathology, Department of Odontology, University of Copenhagen, Copenhagen, Denmark; Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital, Copenhagen, Denmark.
Objectives: The aim was to provide an in-depth characterization of patients hospitalized with severe odontogenic infections (SOI), especially in relation to the origin of the infection. Furthermore, the aim was to generate an overview of which kind of treatment the patients had received before hospitalization and to analyze risk factors for prolonged length of hospital stay.
Material And Methods: The study was a retrospective cross-sectional study, which included patients hospitalized at the University Hospital of Copenhagen, Denmark, with SOI from November 2012 through 2019.
Impact of Oral Infection on Organ Transplantation: A Systematic Review.
J Evid Based Dent Pract
December 2024
Department of Oral Pathology, Faculty of Odontology, Malmö University, Malmö, Sweden.
Article Synopsis
- * The review analyzed nine cohort studies, indicating that lack of dental treatment may lead to increased infectious complications, particularly in liver transplants, while the impact on kidney and lung transplants varied.
- * Overall, the findings suggest that managing oral infections pre- transplantation could be beneficial, but there was no significant link found to mortality or organ rejection rates.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!