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| http://dx.doi.org/10.1002/jha2.395 | DOI Listing |
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Characterization of Platelet Receptors and Their Involvement in Immune Activation of These Cells.
Int J Mol Sci
November 2024
Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.
The article characterises platelets, pointing out the role and contribution of their numerous receptors determining their specific and broad immune activity. Three types of platelet receptors are described, that is, extracellular and intracellular receptors-TLR (toll-like receptors), NLR (NOD-like receptor), and RLR (RIG-I-like receptor); extracellular receptors-selectins and integrins; and their other extracellular receptors-CLR (C-type lectin receptor), CD (cluster of differentiation), TNF (tumour necrosis factor), among others. Outlining the contribution of these numerous platelet receptors to the intravascular immunity, it has been shown that they are formed by their fusion with pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and lifestyle-associated molecular patterns (LAMPs).
View Article and Find Full Text PDFBalancing immune response: SHP1 controls neutrophil activation in inflamed lungs.
J Clin Invest
December 2024
Following respiratory infection or injury, neutrophil hyperactivation can damage surrounding lung tissue by releasing harmful compounds. In this issue of the JCI, Moussavi-Harami and colleagues identified tyrosine phosphatase SHP1 as a key negative regulator of neutrophil activation in acute respiratory distress syndrome (ARDS). Neutrophil-specific Shp1 disruption leads to hyperinflammation, pulmonary hemorrhage, and increased mortality in both sterile and pathogen-induced acute lung injury (ALI).
View Article and Find Full Text PDFSpontaneous natural killer cell lymphoproliferative disorder in a rhesus macaque.
J Vet Diagn Invest
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California National Primate Center, University of California-Davis, Davis, CA, USA.
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Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases.
J Clin Exp Hematop
November 2024
Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Fukushima city, Japan.
Cluster of Differentiation 54 (CD54), also known as intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Although CD54 has been shown to be involved in cell-to-cell adhesion and proliferation of B-cell lymphoma cell lines, the clinical significance of its expression has not yet been elucidated. We analyzed Ki-67 indices, the expression status of CD54 and its receptor (CD11a), and the intercellular distance of tumor cells in 40 diffuse large B-cell lymphoma (DLBCL) cases with vascular invasion to analyze the association of cell adhesion and proliferation status.
View Article and Find Full Text PDFNIR-II scattering gold superclusters for intravascular optical coherence tomography molecular imaging.
Nat Nanotechnol
October 2024
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
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- Currently, intravascular optical coherence tomography (IV-OCT) is primarily used for imaging the structure of arterial plaques, but it lacks the ability to detect molecular changes in the endothelium, which could improve risk assessment for cardiovascular issues.
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