Aim: To explore biomarkers with a tumor stage-dependent expression pattern in patients with colorectal cancer (CRC).
Background: The fourth most common cancer in the world is colorectal cancer (CRC). A variation in the gene expression rate is a common change in cancers initiation and the accumulation of these variation changes the behavior of normal cells and turns them into cancer cells.
Methods: Real-time RT-PCR was used to investigate the expression patterns of the , , , , , and genes in 54 patients with stage I to IV CRC and their relation with clinicopathological features of CRC were analyzed. Results: , and genes are overexpressed in CRC tumor tissues when compared to normal adjacent tissues in all the stages.
Results: , and had-stage dependent expression. Investigation of the association between clinicopathological features and expression pattern of the studied genes revealed; a) a significant relationship between gene expression level and tumor stage, tumor size and lymph node involvement, b) a considerable association between alterations in and expression and lymph node involvement, c) a notable correlation between expression level and the tumor stage and d) a strong correlation between expression and patient's age only.
Conclusion: Our study indicates that expression profiles of these genes either individually or together can be applied as potential biomarkers for prognosis of CRC.
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