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Serum Lidocaine Levels in Adult Patients Undergoing Cardiac Surgery With del Nido Cardioplegia.
Ann Thorac Surg Short Rep
June 2024
Division of Cardiothoracic Surgery, Northwell Health, Manhasset, New York.
Background: Lidocaine in del Nido cardioplegia solution prolongs the refractory period of cardiomyocytes, yielding a longer arrest per dose. Serum lidocaine concentrations >8 mg/L are associated with seizure and cardiotoxicity. We evaluated serum lidocaine concentrations in patients receiving del Nido solution during cardiac surgery.
View Article and Find Full Text PDFSecreted LGALS3BP facilitates distant metastasis of breast cancer.
Breast Cancer Res
January 2025
College of Pharmacy, Seoul National University, Seoul, 08826, South Korea.
Background: Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated with endocrine therapy targeting ER, however, metastatic recurrence occurs in 25% of the patients who have initially been treated. Secreted proteins from tumors play important roles in cancer metastasis but previous methods for isolating secretory proteins had limitations in identifying novel targets.
Methods: We applied an in situ secretory protein labeling technique using TurboID to analyze secretome from tamoxifen-resistant (TAMR) BC.
Endoscopic Debridement, Ostectomy, Release, and Radiofrequency: A Fully Endoscopic Technique for Treating Recalcitrant Plantar Fasciitis.
Arthrosc Tech
December 2024
Department of Orthopaedic Surgery, Sengkang General Hospital, Singapore.
Plantar fasciitis (PF), a common cause of heel pain, primarily results from inflammation of the plantar fascia due to excessive strain. Its complex pathophysiology, influenced by various biomechanical factors, has led to the development of diverse surgical techniques. Most of these techniques, when used in isolation, have shown benefits in treating refractory PF.
View Article and Find Full Text PDF[Isolated osseous tuberculosis : Differential diagnosis of treatment refractory osteomyelitis?].
Unfallchirurgie (Heidelb)
January 2025
Klinik für Orthopädie und Unfallchirurgie, BG Klinikum Duisburg, Großenbaumer Allee 250, 47249, Duisburg, Deutschland.
We report the case of a 66-year-old female patient with a treatment refractory disorder of wound healing of the knee, who had already been treated several times surgically and with antibiotics for several months. The examination revealed a skin defect with a fistula in the region of the knee joint. The X‑ray imaging showed an extensive bony defect of unclear etiology.
View Article and Find Full Text PDFSustained quality-of-life improvements over 10 years after subthalamic nucleus deep brain stimulation for isolated dystonia.
J Neurol
January 2025
Department of Neurology and Institute of Neurology, Ruijin Hospital, Affiliated with Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Background: Bilateral deep brain stimulation (DBS) of subthalamic nucleus (STN) has demonstrated efficacy for ameliorating medication-refractory isolated dystonia. Nonetheless, the paucity of evidence regarding its long-term impact on quality-of-life (QoL) necessitates further investigation.
Objectives: This study aimed to elucidate the longitudinal effects of chronic STN stimulation on QoL in patients suffering from isolated dystonia.
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