AI Article Synopsis
- Researchers are exploring new strategies to combat the deadly malaria parasite Plasmodium falciparum by inhibiting its translation process.
- A new compound has been identified that specifically targets and binds to the enzyme tyrosine aminoacyl-tRNA synthetase in the parasite.
- This binding prevents the incorporation of tyrosine into proteins, potentially leading to the development of safer and more effective antimalarial drugs.
Article Abstract
Inhibiting translation presents a tantalizing strategy to tackle the most virulent human malaria parasite. Xie et al. disclose a compound that binds selectively to Plasmodium falciparum tyrosine aminoacyl-tRNA synthetase, preventing the incorporation of tyrosine into nascent proteins and paving the way for a new generation of safe, effective antimalarials.
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| http://dx.doi.org/10.1016/j.pt.2022.07.001 | DOI Listing |
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