AI Article Synopsis
- Autoimmunity is prevalent in Common Variable Immune Deficiency (CVID) patients, but the exact mechanisms behind its development remain unclear.
- Data from a study involving 122 CVID patients distinguished between those with and without autoimmune conditions, revealing that 45.1% showed signs of autoimmunity, with immune thrombocytopenia being the most frequent manifestation.
- The study found unique immune profiles in patients with autoimmune cytopenias, indicating potential biomarkers or phenotypic features that differentiate them from other CVID patients.
Article Abstract
Introduction: Autoimmunity is a common feature in CVID patients. To date the mechanisms leading to the development of such complications are not fully elucidated.
Materials And Methods: Data from 122 CVID patients subdivided in three groups based on the absence of autoimmunity (n-AI) or the presence of hematologic autoimmune phenomena (Cy-AI) or non-hematologic autoimmune phenomena (n-Cy-AI) were evaluated.
Results: We identified a total of 128 autoimmune manifestations in 55/122 patients (45.1%). 30/122 (24.6%) patients presented hematologic autoimmune phenomena while 29/122 (23.8%) presented gastrointestinal autoimmune involvement. Immune thrombocytopenia was the most common manifestation (27/122; 22.1%), followed by autoimmune hemolytic anemia (18/122; 14.8%) and autoimmune enteropathy (17/122; 13.9%). Cy-AI patients displayed higher CD4 effector memory and terminally differentiated CD8 cells with lower percentages of naïve and recent thymic emigrants (RTEs) CD4 cells and a significant expansion of the CD19CD21 population.
Conclusions: CVID patients developing autoimmune cytopenias display characteristic immune phenotypic features.
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| http://dx.doi.org/10.1016/j.clim.2022.109077 | DOI Listing |
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