We study the problem of experiment design to learn causal structures from interventional data. We consider an active learning setting in which the experimenter decides to intervene on one of the variables in the system in each step and uses the results of the intervention to recover further causal relationships among the variables. The goal is to fully identify the causal structures with minimum number of interventions. We present the first deep reinforcement learning based solution for the problem of experiment design. In the proposed method, we embed input graphs to vectors using a graph neural network and feed them to another neural network which outputs a variable for performing intervention in each step. Both networks are trained jointly via a Q-iteration algorithm. Experimental results show that the proposed method achieves competitive performance in recovering causal structures with respect to previous works, while significantly reducing execution time in dense graphs.
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http://dx.doi.org/10.1016/j.neunet.2022.06.028 | DOI Listing |
J Neurosurg Case Lessons
January 2025
Department of Neurosurgery, General Hospital Bamberg, Bamberg, Germany.
Background: Optic nerve schwannomas are an extremely rare pathology in neurosurgery. Their origin is rather debatable given the structure of the optic nerve, which does not typically have Schwann cells therein. However, a number of clinical cases of optic nerve tumors classified as schwannomas have been described in the literature.
View Article and Find Full Text PDFJ Urol
January 2025
Division of Urology, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Purpose: Urinary incontinence (UI) is common in nulliparous female elite athletes, but underlying pathophysiology is inadequately understood. We examined urinary symptoms and associated pelvic floor anatomy and function in this population, hypothesizing that athletes with UI would exhibit pelvic floor findings seen in older incontinent women (e.g.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Department of Marine Microbiology and Biogeochemistry, Royal Netherlands Institute for Sea Research (NIOZ), Den Burg 1790 AB, The Netherlands.
Heterocytes, specialized cells for nitrogen fixation in cyanobacteria, are surrounded by heterocyte glycolipids (HGs), which contribute to protection of the nitrogenase enzyme from oxygen. Diverse HGs preserve in the sediment and have been widely used as evidence of past nitrogen fixation, and structural variation has been suggested to preserve taxonomic information and reflect paleoenvironmental conditions. Here, by comprehensive HG identification and screening of HG biosynthetic gene clusters throughout cyanobacteria, we reconstruct the convergent evolutionary history of HG structure, in which different clades produce the same HGs.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
School of Biological Sciences, Life Sciences Department, University of Bristol, Bristol BS8 1TQ, England.
Electric fields in terrestrial environments are used by caterpillars to detect their predators, as foraging cues by pollinators, and facilitate ballooning by spiders. This study shows that electric fields facilitate transportation and detection of hummingbirds in a guild of tropical phoretic mites. Hummingbird flower mites feed on nectar and pollen and complete their life cycle inside flowers.
View Article and Find Full Text PDFDev Psychol
January 2025
Adelaide Dental School, University of Adelaide.
Adolescence is a period in which peer problems and emotional symptoms markedly increase in prevalence. However, the causal mechanisms regarding how peer problems cause emotional symptoms at a behavioral level and vice versa remain unknown. To address this gap, the present study investigated the longitudinal network of peer problems and emotional symptoms among Australian adolescents aged 12-14 years.
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