We report the clinical case of AB, a right-handed 19-year-old woman who presents severe developmental topographical disorientation, a relatively rare syndrome, leading to difficulties in navigating in familiar (and novel) environments. This symptomatology appears without acquired cerebral damage (MRI described as normal) nor more global cognitive disability (high degree of education achieved). An extensive assessment of spatial cognition with different aspects of underlying cognitive processes is first presented. Second, the patient's preserved cognitive abilities and her major difficulties in calculation, as well as her attention deficit, as seen in a detailed neuropsychological assessment, are reported. For the first time to our knowledge, we show that developmental topographical disorientation can be associated with other developmental cognitive disorders affecting number processing (dyscalculia) and attention (Attention Deficit-Hyperactivity Disorder (ADHD)). We discuss the links between these different cognitive processes in relation to visuo-spatial working memory and magnitude representation, which could represent common denominators for all these syndromes. This case report highlights the importance of thoroughly assessing potentially associated neurocognitive disorders in developmental topographical disorientation. In addition, it highlights the necessity to keep in mind the prevalence of spatial difficulties in the assessment of children and adolescents with other neurodevelopmental syndromes. Finally, this case study raises a new question about the nosology of developmental disorders affecting the visuo-spatial and spatial domains.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuropsychologia.2022.108331 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Geospatial analysis of sports tourism resources in China's urban clusters: a case study of the Sichuan-Chongqing region utilizing GIS and the geographic detector.
Front Sports Act Living
December 2024
School of Physical Education, Southwest University, Chongqing, China.
Introduction: This study aims to elucidate the temporal and spatial distribution patterns of sports tourism resources within the Sichuan-Chongqing Urban Agglomeration, examining how these distributions reflect the developmental pathways of urban regions. The theoretical framework posits that the availability and allocation of sports tourism resources are influenced by various geographical and socio-economic factors, with topography, economic conditions, and population density playing pivotal roles in determining their distribution and development.
Methods: Utilizing GeoDetector technology alongside indices such as the Geographic Concentration Index and the Disparities Index, we conducted a comprehensive analysis of the spatiotemporal dynamics of sports tourism resources, revealing that the distribution of these resources serves as a key indicator of urban development speed.
Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.
Proc Natl Acad Sci U S A
October 2024
Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Article Synopsis
- * Researchers used advanced imaging techniques to analyze how different parts of the hippocampus connect with specific cortical pathways during brain development, with the front part linked to the anterior temporal pathway and the back part to the posterior medial pathway.
- * The study found that as brains develop, there is a shift in connectivity from the back to the front of the hippocampus, emphasizing its role in episodic memory and identifying key regions that influence how the hippocampus integrates into broader brain functions.
The development of the external genitals in female human embryos and foetuses. Part 1: Perineal thick skin, clitoris and labia.
J Anat
October 2024
Department of Anatomy & Embryology, Maastricht University, Maastricht, The Netherlands.
Concomitant with the rupture of the cloacal membrane in the 6th week of development, the intermediate layer of the perineal-skin epithelium thickens. We investigated its distribution and the development of the corresponding subcutaneous compartments in serial sections of female human embryos and foetuses and prepared 3D reconstructions to establish topographic relations. The thick-skin area becomes restricted to the outlets of the genital and intestinal tracts.
View Article and Find Full Text PDFPongo's ecological diversity from dental macrowear analysis.
Am J Biol Anthropol
December 2024
Department of Paleoanthropology, Senckenberg Research Institute and Natural History Museum Frankfurt, Frankfurt, Germany.
Objectives: Orangutans are found in tropical rainforests of Borneo (Pongo pygmaeus) and Sumatra (Pongo abelii and Pongo tapanuliensis), and they are primarily considered frugivorous species. However, ecological studies reported differences in feeding behavior between these species. P.
View Article and Find Full Text PDFSegregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses.
bioRxiv
September 2024
Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
The basal ganglia control multiple sensorimotor behaviors though anatomically segregated and topographically organized subcircuits with outputs to specific downstream circuits. However, it is unclear how the anatomical organization of basal ganglia output circuits relates to the molecular diversity of cell types. Here, we demonstrate that the major output nucleus of the basal ganglia, the substantia nigra pars reticulata (SNr) is comprised of transcriptomically distinct subclasses that reflect its distinct progenitor lineages.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!