AI Article Synopsis
- The study investigates how transplanting fecal microbiota in young rats can influence health or disease outcomes later in life, particularly focusing on lean and obese male and female Wistar rats.
- Using a model that induces parental obesity, researchers evaluated the offspring's health metrics after they received either obese or lean microbiota through feeding during early development.
- Results showed that male rats with an obese microbiota gained more weight and had metabolic issues, while those with a lean microbiota were healthier; female rats did not show significant changes in metabolism from the microbiota transplant.
Article Abstract
Background: The intestinal microbiota is involved in many physiological processes. However, the effects of microbiota in metabolic programming still unknow. We evaluated whether the transplantation of fecal microbiota during early life can program health or disease during adulthood in a model of lean and obese male and female Wistar rats.
Methods: Parental obesity were induced using a small litter (SL, 3 pups/dam) model. At 90 d old, normal litter (NL, 9 pups/dam) and SL males and females (parents) from different litters were mated: NL male vs. NL female; SL male vs. SL female. After birth, male and female offspring rats were also standardized in normal litters or small litters . From the 10 until 25 d of life, the NL and SL male and female offspring received via gavage of a solution containing the diluted feces of the opposite dam (fecal microbiota, M) or saline solution (S). At 90 d of age, biometric and biochemical parameters were assessed.
Results: NLM male rats transplanted with obese microbiota showed increased body weight, and fat pad deposition, hyperinsulinemia, glucose intolerance and dyslipidemia. SLM male rats transplanted with lean microbiota had decreased retroperitoneal and mesenteric fat, triglycerides and VLDL levels and improvement of glucose tolerance. Despite SLM female rats showed higher visceral fat, microbiota transplantation in female rats caused no changes in these parameters compared with control groups.
Conclusion: Fecal microbiota transplantation during lactation induces long-term effects on the metabolism of male Wistar rats. However, female rats were resistant to metabolic alterations caused by the treatment.
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| http://dx.doi.org/10.1016/j.arcmed.2022.06.007 | DOI Listing |
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