The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone─the core structure of many antibiotics.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368603 | PMC |
| http://dx.doi.org/10.1021/acs.joc.2c00973 | DOI Listing |
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