Purpose: Numerous experimental and targeted therapies are under investigation for patients with cholangiocarcinoma (CCA). Objective health-related quality of life (HRQoL) data for patients receiving these therapies are limited.
Methods: Patients engaged in the Cholangiocarcinoma Foundation completed two validated HRQoL surveys: Functional Assessment of Cancer Therapy (FACT)-Hepatobiliary and COmprehensive Score for financial Toxicity (COST).
Results: Two hundred eight patients were included. Seventy-five percent had intrahepatic CCA and 57% underwent resection, of which 48% had disease recurrence. Twenty-two percent enrolled in a clinical trial and 80% underwent molecular profiling, of which 29% received targeted therapy. While patients enrolled in a clinical trial or received targeted therapy reported similar HRQoL compared to those who did not, they reported higher financial toxicity (p = 0.05 and p = 0.01, respectively).
Conclusion: Enrollment in a clinical trial or receipt of targeted therapy do not affect a patient's physical, emotional, social, or functional well-being. However, patients report higher financial burden. These therapies are mainly offered in the advanced setting after significant financial strain has been endured and are often only available at large academic centers, creating a physical barrier to access. These findings underscore the need to increase availability and eliminate physical and financial barriers that threaten access and utilization of personalized and progressive therapies.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580504 | PMC |
http://dx.doi.org/10.1002/jso.27012 | DOI Listing |
Extremophiles
December 2024
Miami College, Henan University, Kaifeng, 475000, Henan, China.
Azo dye wastewater has garnered significant attention from researchers because of its association with high-temperature, high-salt, and high-alkali conditions. In this study, consortium ZZ efficiently decolorized brown D3G under halophilic and thermophilic conditions. he results indicated that consortium ZZ, which was mainly dominated by Marinobacter, Bacillus, and Halomonas, was achieved decolorization rates ranging from 1 to 10% at temperatures between 40 °C and 50 °C, while maintaining a pH range of 7 to 10 for direct brown D3G degradation.
View Article and Find Full Text PDFJ Virol
December 2024
Citrus Research and Education Center, University of Florida, Lake Alfred, Florida, USA.
Unlabelled: transmits Liberibacter asiaticus (CLas) between citrus plants which causes the expression of huanglongbing disease in citrus. flavi-like virus (DcFLV) co-occurs intracellularly with CLas in populations in the field. However, the impact(s) of DcFLV presence on the insect vector and its interaction with the CLas phytopathogen remain unclear.
View Article and Find Full Text PDFFront Nutr
December 2024
Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Background: Growing evidence indicates that metal implants influence the body's oxidative stress status, which in turn affects the degradation and stability of metal implants. The oxidative balance score (OBS) is a composite indicator, reflecting the overall oxidative balance of pro-and antioxidants of the human body. However, the associations between OBS and the level of metal ions on the population with metal implants remain to be elucidated.
View Article and Find Full Text PDFFront Nutr
December 2024
Faculty of Physical Education and Sport, Dunarea de Jos University of Galati, Galati, Romania.
Introduction: It is known that combat athletes frequently lose weight before a competition. This study aimed to determine the weight loss methods before an official championship and the effects of these weight loss methods on the performance of wrestlers.
Method: The sample of the study consisted of 350 competitive wrestlers.
Front Nutr
December 2024
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Introduction: Hypertension (HTN) is a prevalent condition associated with numerous cardiovascular and non-cardiac complications. Lifestyle interventions, including dietary adjustments, offer promising avenues for hypertension management. However, the precise relationship between dietary antioxidants and hypertension risk necessitates further investigation.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!