AI Article Synopsis
- In vitro methods for testing SARS-CoV-2 treatments may not accurately reflect real infection contexts, and mouse models have limitations.
- The study introduces a novel ex vivo technique that uses nasal epithelial cells collected from COVID-19 patients.
- This approach enables researchers to directly observe immune responses and evaluate new treatments on patient-derived cells.
Article Abstract
The use of in vitro methods of infecting cell lines to test new treatments for SARS-CoV-2 does not always recapitulate the real context of the infection, and mouse models for SARS-CoV-2 infection are limited. Here we describe a novel ex vivo approach by collecting, isolating, and culturing nasal epithelial cells obtained from patients with COVID-19. This technique allows us to study immune responses and test new treatments directly on cells from patients naturally infected with SARS-CoV-2.
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| http://dx.doi.org/10.1007/978-1-0716-2395-4_28 | DOI Listing |
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