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SLGT2 Inhibitor Rescues Myelopoiesis in G6PC3 Deficiency. | LitMetric

AI Article Synopsis

  • * In G6PC3-deficient mice, the accumulation of 1,5AG6P leads to neutrophil dysfunction and cell death, while the sodium glucose cotransporter 2 (SGLT2) inhibitor helps lower blood levels of 1,5AG and improves neutrophil counts.
  • * A case study involving a 30-year-old woman with G6PC3 deficiency showed that treatment with an SGLT2

Article Abstract

The energy metabolism of myeloid cells depends primarily on glycolysis. 1,5-Anhydroglucitol (1,5AG), a natural monosaccharide, is erroneously phosphorylated by glucose-phosphorylating enzymes to produce 1,5-anhydroglucitol-6-phosphate (1,5AG6P), a powerful inhibitor of hexokinases. The endoplasmic reticulum transporter (SLC37A4/G6PT) and the phosphatase G6PC3 cooperate to dephosphorylate 1,5AG6P. Failure to eliminate 1,5AG6P is the mechanism of neutrophil dysfunction and death in G6PC3-deficient mice. Sodium glucose cotransporter 2 (SLGT2) inhibitor reduces 1,5AG level in the blood and restores the neutrophil count in G6PC3-deficient mice. In the investigator-initiated study, a 30-year-old G6PC3-deficient woman with recurrent infections, distressing gastrointestinal symptoms, and multi-lineage cytopenia was treated with an SLGT2-inhibitor. A significant increase in all the hematopoietic cell lineages and substantial improvement in the quality of life was observed.

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Source
http://dx.doi.org/10.1007/s10875-022-01323-4DOI Listing

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