Pyranopyrazoles are bicyclic nitrogen-containing heterocycles having broadspectrum bioactivities, which may act as anti-cancer, anti-inflammatory, antibacterial, antifungal, insecticidal and molluscicidal agents. Pyranopyrazoles have become an attractive scaffold for the discovery of new drugs due to the diverse range of bioactivities associated with this nucleus. In this review, we have focused on the medicinal importance of pyranopyrazole derivatives and highlighted different routes for the synthesis of pyranopyrazole derivatives using inexpensive and commonly available starting materials.
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http://dx.doi.org/10.2174/0929867329666220714093848 | DOI Listing |
Int J Biol Macromol
September 2024
College of Civil Engineering and Architecture, Guangxi University, Nanning 530004, China.
In this project, a highly efficient catalyst with a remarkable yield of over 97 % was developed for the synthesis of dihydropyrano[2,3-c] pyrazole derivatives. A Gellan Gum-Cellulose hydrogel was prepared using Glutaraldehyde as the cross-linker, which served as the matrix for further modifications. Synthesized graphene oxide was then incorporated into the hydrogel structure using a modified Hummers method, enhancing the catalytic properties of the material.
View Article and Find Full Text PDFPharmaceuticals (Basel)
February 2024
Chemistry Department, Faculty of Science, Menofia University, Shebin El-Kom 32511, Egypt.
The SARS-CoV-2 pandemic at the end of 2019 had major worldwide health and economic consequences. Until effective vaccination approaches were created, the healthcare sectors endured a shortage of operative treatments that might prevent the infection's spread. As a result, academia and the pharmaceutical industry prioritized the development of SARS-CoV2 antiviral medication.
View Article and Find Full Text PDFRecent Adv Antiinfect Drug Discov
May 2024
Department of Pharmaceutical Chemistry, All India Shri Shivaji Memorial Society's College of Pharmacy, Pune 411001, Maharashtra, India.
Background: Every year Invasive Fungal Infections (IFI) are globally affecting millions of people. have been reported as the most infectious and mortality-inducing fungal strains among all pathogenic fungi.
Aims & Objectives: To tackle this problem in the current study Pyranopyrazoles and Pyrazolopyrano- pyrimidine derivatives were developed using molecular hybridization, green chemistry and one-pot multicomponent reaction.
Bioorg Chem
March 2024
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt.
A new series of pyranopyrazole-based derivatives were designed and synthesized. The synthesized compounds were assessed for their cytotoxic efficacy against A549 human lung carcinoma and MCF-7 human breast carcinoma cell lines. Three compounds (1b, 4b, and 7b) exhibited 1.
View Article and Find Full Text PDFSci Rep
November 2023
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Pyranopyrazole derivatives have a vital role in the class of organic compounds because of their broad spectrum of biological and pharmacological importance. Our current goal is the [3 + 3] cycloaddition of benzoyl isothiocyanate and pyrazolone 1 to undergo oxidation cyclization, producing pyrazoloxadiazine 3. The diol 5 was obtained as a condensation of two equivalents of 1 with thiophene-2-carboxaldehyde in acetic acid above the sodium acetate mixture.
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