Implementing an effective software solution is an important step in managing a portfolio of core facilities. Though commercial options are available, developing or adopting a custom platform is a viable path for many institutions. At Northwestern University (NU), the cores program was reorganized beginning in 2008, and we pursued the latter path in order to retain control of the development priorities and to ensure integration with other enterprise systems. This manuscript describes our experience and results after a decade of effort. The platform, named NUcore, began enrollment in 2011, and full enrollment was achieved in 2019. Key features of NUcore include a stable and secure environment, a responsive and intuitive interface for users and core staff, seamless integration with the university financial system, rules and restrictions to ensure compliance, and both core-specific and enterprise reporting. NUcore now supports nearly half of all sponsored award dollars at NU at a cost of only 1 cent per dollar of business transacted. On average, there are over 4000 active users each year. NUcore is managed as an open-source project, available at no cost to any organization. Five academic organizations currently use the NUcore code base. For NU, NUcore has been a substantial success, and continuous development will ensure that it meets the future needs of our university and its cores.
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http://dx.doi.org/10.7171/3fc1f5fe.3a4b405c | DOI Listing |
Eur J Med Chem
January 2025
Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Healthand, Department of Frontiers Science Center for Disease-related Molecular Network, Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:
NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.
View Article and Find Full Text PDFMetabolomics
January 2025
Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Introduction: Hemodynamic forces play a crucial role in modulating endothelial cell (EC) behavior, significantly influencing blood vessel responses. While traditional in vitro studies often explore ECs under static conditions, ECs are exposed to various hemodynamic forces in vivo. This study investigates how wall shear stress (WSS) influences EC metabolism, focusing on the interplay between WSS and key metabolic pathways.
View Article and Find Full Text PDFJ Neurochem
January 2025
Nantes Université, INRAE, UMR 1280, Physiologie des Adaptations Nutritionnelles, Nantes, France.
Obesity leads to a number of health problems, including learning and memory deficits that can be passed on to the offspring via a developmental programming process. However, the mechanisms involved in the deleterious effects of obesity on cognition remain largely unknown. This study aimed to assess the impact of obesity on the production of sphingolipids (ceramides and sphingomyelins) in the brain and its relationship with the learning deficits displayed by obese individuals.
View Article and Find Full Text PDFACS Photonics
January 2025
Photonic Nanomaterials, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Colloidal semiconductor nanocrystals (NCs) are an efficient and cost-effective class of nanomaterials for optoelectronic applications. Advancements in NC-based optoelectronic devices have resulted from progress in synthetic chemistry, adjustable surface properties, and optimized device architectures. Semiconductor nanoplatelets (NPLs) stand out among other NCs due to their precise growth control, yielding uniform thickness with submonolayer roughness.
View Article and Find Full Text PDFJ Leukoc Biol
January 2025
Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, India.
Osteoporosis is a skeletal condition characterized by the deterioration of bone tissue. The immune system plays a crucial role in maintaining bone homeostasis and combating the development of osteoporosis. Immunoporosis is the term used to describe the recent convergence of research on the immune system's role in osteoporosis.
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