Neuron modelling helps to understand the brain behavior through the interaction between neurons, but its mechanism remains unclear. In this paper, the spatiotemporal patterns is investigated in a general networked Hindmarsh-Rose (HR) model. The stability of the network-organized system without delay is analyzed to show the effect of the network on Turing instability through the Hurwitz criterion, and the conditions of Turing instability are obtained. Once the analysis of the zero-delayed system is completed, the critical value of the delay is derived to illustrate the profound impact of the given network on the collected behaviors. It is found that the difference between the collected current and the outgoing current plays a crucial role in neuronal activity, which can be used to explain the generation mechanism of the short-term memory. Finally, the numerical simulation is presented to verify the proposed theoretical results.
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http://dx.doi.org/10.3389/fphys.2022.936982 | DOI Listing |
R Soc Open Sci
January 2025
Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa 9200293, Japan.
Acute myeloid leukaemia (AML) is a haematologic malignancy with high relapse rates in both adults and children. Leukaemic stem cells (LSCs) are central to leukaemopoiesis, treatment response and relapse and frequently associated with measurable residual disease (MRD). However, the dynamics of LSCs within the AML microenvironment is not fully understood.
View Article and Find Full Text PDFHeliyon
July 2024
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China.
Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive neuroimaging technique widely utilized in the research of Autism Spectrum Disorder (ASD), providing preliminary insights into the potential biological mechanisms underlying ASD. Deep learning techniques have demonstrated significant potential in the analysis of rs-fMRI. However, accurately distinguishing between healthy control group and ASD has been a longstanding challenge.
View Article and Find Full Text PDFBiomed Opt Express
January 2025
Warsaw University of Technology, Institute of Micromechanics and Photonics, 8 Sw. A. Boboli St., 02-525 Warsaw, Poland.
A fair comparison of multiple live cell cultures requires examining them under identical environmental conditions, which can only be done accurately if all cells are prepared simultaneously and studied at the same time and place. This contribution introduces a multiplexed lensless digital holographic microscopy system (MLS), enabling synchronous, label-free, quantitative observation of multiple live cell cultures with single-cell precision. The innovation of this setup lies in its ability to robustly compare the behaviour, i.
View Article and Find Full Text PDFImmunometabolism (Cobham)
January 2025
Institute for Systems Biology, Seattle, WA, USA.
The nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing-protein 3 (NLRP3) inflammasome is a multiprotein complex that plays a critical role in the innate immune response to both infections and sterile stressors. Dysregulated NLRP3 activation has been implicated in a variety of autoimmune and inflammatory diseases, including cryopyrin-associated periodic fever syndromes, diabetes, atherosclerosis, Alzheimer's disease, inflammatory bowel disease, and cancer. Consequently, fine-tuning NLRP3 activity holds significant therapeutic potential.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Department of Physical Chemistry, Sciences II, University of Geneva, 30 Quai Ernest Ansermet, Geneva 1211, Switzerland.
The formation of protein condensates (droplets) via liquid-liquid phase separation (LLPS) is a commonly observed phenomenon in vitro. Changing the environmental properties with cosolutes, molecular crowders, protein partners, temperature, pressure, etc. has been shown to favor or disfavor the formation of protein droplets by fine-tuning the water-water, water-protein, and protein-protein interactions.
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