AI Article Synopsis
- A pregnant woman with a mild SARS-CoV-2 infection gave birth to a preterm infant at 32 weeks gestation.
- The infant was isolated after birth but developed severe respiratory issues, ultimately leading to death due to multisystem inflammatory syndrome within a week.
- Genome sequencing confirmed the transmission of the P.1 (gamma) variant from the mother to the newborn, marking this as the first documented case of vertical transmission of this variant associated with severe outcomes in the neonate.
Article Abstract
Herein we describe a mild symptomatic real-time reverse transcriptase- polymerase chain reaction-confirmed coronavirus 2 (SARS-CoV-2) infection in a pregnant woman who gave birth to a preterm infant, 32 weeks gestational age. The neonate was immediately isolated after delivery and developed severe respiratory disease that progressed to multisystem inflammatory syndrome and death on the seventh day of life. Genome sequencing detected the P.1 (gamma) variant in samples obtained at hospital admission (mother) and on the first (10h) and 13th days of life (neonate). Complete homology (mother's and newborn's sequences) confirmed vertical transmission. To our knowledge, this is the first report of vertically-transmitted SARS-CoV-2 P.1 (gamma) variant in a mild symptomatic infection in pregnancy associated with fatal COVID in a neonate.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273115 | PMC |
| http://dx.doi.org/10.1016/j.bjid.2022.102385 | DOI Listing |
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