Scanning x-ray microdiffraction: In situ molecular imaging of tissue and materials.

Curr Opin Struct Biol

Bioengineering Department, Northeastern University, Boston, MA, USA. Electronic address:

Published: August 2022

Scanning x-ray microdiffraction of complex tissues and materials is an emerging method for the study of macromolecular structures in situ, providing information on the way molecular constituents are arranged and interact with their microenvironment. Acting as a bridge between high-resolution images of individual constituents and lower resolution microscopies that generate global views of material, scanning microdiffraction provides an approach to study the functioning of complex tissues across multiple length scales. Here, we discuss the methodology, summarize results from recent studies, and discuss the potential of the technique for future studies coordinated with other biophysical techniques.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317818PMC
http://dx.doi.org/10.1016/j.sbi.2022.102421DOI Listing

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