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A case of hepatocellular carcinoma with long-term survival by multidisciplinary treatment for cranial and skeletal muscle metastases. | LitMetric

AI Article Synopsis

  • A 55-year-old male with hepatocellular carcinoma (HCC) experienced metastases in his skull and muscles, prompting multidisciplinary treatment, including surgery and various medications.
  • After initial successes with sorafenib and surgical resection, the patient faced ineffective treatments and worsening metastases, leading to increased disability and pain.
  • Ultimately, sorafenib was re-administered, along with targeted therapies like resection and radiation for the dural and muscle metastases, allowing him to manage his condition and survive for four years post-surgery.

Article Abstract

We report a case in which multidisciplinary treatment was effective for hepatocellular carcinoma (HCC) with cranial and skeletal muscle metastases. A 55-year-old male with HCC received sorafenib for lung metastases. He was admitted to our hospital due to the skull metastasis detected by fluorodeoxyglucose positron emission tomography (FDG-PET). The patient underwent resection for skull metastasis. After the surgical treatment, he was treated with sorafenib again. Eight months after craniectomy, FDG-PET showed FDG uptake in the semimembranosus and semitendinosus muscles. Histopathological examination of the muscle biopsy revealed HCC muscle metastasis. Sorafenib treatment was discontinued. The investigational new drug (tegafur-gimeracil-oteracil) and tegafur-uracil were used for the treatment. These treatments proved to be ineffective as the lung metastases enlarged and new metastases appeared on the mediastinal lymph nodes and dura cava. The patient was unable to walk due to the enlarged thigh muscle metastases. Sorafenib was re-administered, which reduced the enlargement of the lung and mediastinal lymph nodes. Dural metastases were treated with resection and radiotherapy. Additional radiation therapy to the thigh muscles relieved the patient from pain experienced during walking. Sorafenib treatment was continued for the next 3 years. The patient survived for 4 years after the skull resection.

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Source
http://dx.doi.org/10.1007/s12328-022-01669-7DOI Listing

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