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Drug Decriminalization and Fatal Traffic Crashes: Evidence From BM110 in Oregon.
Health Econ
January 2025
Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Oregon Ballot Measure 110 (BM 110) reduced the penalties for non-commercial possession of a controlled substance, downgrading them from a felony or misdemeanor to a new Class E violation, punishable by a maximum $100 fine. In this paper, we investigate whether BM 110 was associated with changes in drug-related fatal traffic crashes in Oregon after its implementation in February 2021. To do so, we used Fatality Analysis Reporting System (FARS) data from 2018 to 2021 to calculate population-adjusted state-level drug-related fatal traffic crashes.
View Article and Find Full Text PDFArterial Stiffness and Markers of Atrial Myopathy.
Ann Noninvasive Electrocardiol
March 2025
Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Background: Arterial stiffness, measured using carotid-femoral pulse wave velocity (c-f PWV) and heart rate-corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross-sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk.
Methods: We included 1050 participants (age 57 ± 4.
"Cell dedifferentiation" versus "evolutionary reversal" theories of cancer: The direct contest of transcriptomic features.
Int J Cancer
January 2025
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Cell dedifferentiation is considered an important hallmark of cancer. The atavistic reversal to a unicellular-like (UC) state is a less widely accepted concept, so far not included in the conventional hallmarks. The activated expression of ontogenetically earlier and evolutionary earlier genes in cancers supports both theories because ontogenesis partially recapitulates phylogenesis during cell differentiation (the cellular biogenetic law).
View Article and Find Full Text PDFMorphological Criteria for Staging Near-Hatching Embryos of the Domesticated Mallard (Anas platyrhynchos) and Swan Goose (Anser cygnoides).
J Morphol
February 2025
Department of Earth Sciences, University of Cambridge, Cambridge, UK.
Studying avian embryology necessitates reliable and precise staging tables-descriptions of embryonic features appearing during development that are used to approximate the extent of embryonic development from fertilisation to hatching. Staging tables for waterfowl (Anseriformes) have previously been established based on morphological features from fertilisation to approximately 10 days before hatching. Embryonic changes over the final 10 days of pre-hatching development have also been documented and proposed as useful staging criteria.
View Article and Find Full Text PDF[Systemic mechanisms of premature aging and their correction by complex physiotherapy application].
Vopr Kurortol Fizioter Lech Fiz Kult
January 2025
Federal State Budgetary Scientific Institution «Russian Scientific Center of Surgery named after Academician B.V. Petrovsky», Moscow, Russia.
Unlabelled: Rationale: Human aging is accompanied by various somatic diseases that increase the biological age and reduce the period of active longevity. For the development of effective methods of premature aging prevention it is necessary to expand the search of predictors of forming pathological reactions, their system analysis and selection of the factors of influence capable to activate the processes of sanogenesis.
Objective: System analysis of pathological changes in various functional systems of the organism, formed in the process of ontogenesis, and evaluation of the effectiveness of the preventive potential of polymodal physiotherapy in terms of preserving the level of health in elderly patients.
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