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Disrupting SARS-CoV-2 Spike Protein Activity: A Virtual Screening and Binding Assay Study.
Int J Mol Sci
December 2024
Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, 4050-313 Porto, Portugal.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that emerged in late 2019 and rapidly spread worldwide, causing the COVID-19 pandemic. The spike glycoprotein (S protein) plays a crucial role in viral target recognition and entry by interacting with angiotensin, converting enzyme 2 (ACE2), the functional receptor for the virus, via its receptor binding domain (RBD). The RBD availability for this interaction can be influenced by external factors, such as fatty acids.
View Article and Find Full Text PDFEffect of temperature on circadian clock functioning of trees in the context of global warming.
New Phytol
January 2025
Instituto de Investigaciones Forestales y Agropecuarias Bariloche, Instituto Nacional de Tecnología Agropecuaria, Estación Experimental Bariloche - Consejo Nacional de Investigaciones Científicas y Técnicas (INTA EEA Bariloche-CONICET), San Carlos de Bariloche, Río Negro, R8403DVZ, Argentina.
Plant survival in a warmer world requires the timely adjustment of biological processes to cyclical changes in the new environment. Circadian oscillators have been proposed to contribute to thermal adaptation and plasticity. However, the influence of temperature on circadian clock performance and its impact on plant behaviour in natural ecosystems are not well-understood.
View Article and Find Full Text PDFBlunt trauma-induced complete esophageal avulsion: A case report on surgical intervention and clinical insights.
Trauma Case Rep
December 2024
Northeast Georgia Medical Center, Trauma and Acute Care Surgery Department, Gainesville, GA 30501, USA.
Blunt esophageal injury is an exceptionally rare condition, with complete esophageal avulsion being almost unprecedented in adults. This case study details the clinical presentation, surgical management, and postoperative course of a 50-year-old male who sustained a complete esophageal avulsion following blunt abdominal trauma. The patient presented with increasing abdominal pain two hours after falling while stepping up onto a high truck step, striking his upper abdomen on the step.
View Article and Find Full Text PDFDifferences in Patient Access to Newly Approved Antibacterial Drugs in EU/EEA Countries.
Antibiotics (Basel)
November 2024
Department of Health Technology Assessment, Faculty of Public Health, Medical University-Sofia, 1527 Sofia, Bulgaria.
Unlabelled: The introduction of antibiotics in the beginning of the 20th century was one of the most important scientific breakthroughs in history. However, in recent decades, the growing threat of antimicrobial resistance (AMR) has shown the limitations of the current research and development programs for new antimicrobial drugs. In the last decade, 20 antibiotics, 7 β-lactam/β-lactamase inhibitor (BL/BLI) combinations and 4 non-traditional antibacterial drugs have been launched worldwide.
View Article and Find Full Text PDFRole of Endoscopic Endonasal Approach for GH-Secreting Tumors.
Front Horm Res
November 2024
IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma Neurochirurgia Ipofisi- Pituitary Unit, Bologna, Italy.
Introduction: Endoscopic endonasal approach (EEA) plays a central role in the treatment of GH-secreting pituitary adenomas (PAs)/pituitary neuroendocrine tumors (PitNETs), allowing to treat not only micro- or regular macro- PAs/PitNEts, but also more complex cases, otherwise requiring a transcranial or other open approaches.
Materials And Methods: All consecutive cases of GH-secreting PAs/PitNETs treated by EEA from May 1998 to June 2023 at our Institution were included. Patients clinical, bio-chemical, and neuroradiological features were considered, as well the surgical approach adopted for each case and its related complications.
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