Colorectal peritoneal metastases (CRPM) can be resistant to the chemotherapy agent (oxaliplatin) most employed, up until recently, as hyperthermic intraperitoneal chemotherapy (HIPEC). Glutathione-mediated inactivation of oxaliplatin can be substantially reduced by genomic deletion of the gene or pharmacological inhibition of glutamate-cysteine ligase in CRPM tumouroids. These discoveries may rekindle the enthusiasm for HIPEC in concert with cytoreductive surgery, which has been employed to manage patients with this once-nihilistic form of stage-IV disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345916 | PMC |
| http://dx.doi.org/10.1038/s41416-022-01905-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Understanding Individual Differences in Happiness Sources and Implications for Health Technology Design: Exploratory Analysis of an Open Dataset.
JMIR Form Res
January 2025
School of Psychology, Ulster University, Coleraine, United Kingdom.
Background: Psychologists have developed frameworks to understand many constructs, which have subsequently informed the design of digital mental health interventions (DMHIs) aimed at improving mental health outcomes. The science of happiness is one such domain that holds significant applied importance due to its links to well-being and evidence that happiness can be cultivated through interventions. However, as with many constructs, the unique ways in which individuals experience happiness present major challenges for designing personalized DMHIs.
View Article and Find Full Text PDFUnderstanding the vital role of campus-based food pantries: Insights into usage patterns, characteristics and eating behaviors among private university students.
J Am Coll Health
January 2025
Department of Health and Sport Sciences, Ruth S. Ammon College of Education and Health Sciences, Adelphi University, Garden City, New York, USA.
This study examined characteristics and usage patterns of students who use a campus-based food pantry at a private university. Student clients of a campus-based food pantry at a private university ( = 30). A qualitative study was conducted using semi-structured interviews.
View Article and Find Full Text PDFDesign Characteristics of Augmentative and Alternative Communication Interfaces for Children With Cortical Visual Impairment: Results From Two Focus Groups With Vision Professionals.
Am J Speech Lang Pathol
January 2025
Department of Speech Pathology, Nationwide Children's Hospital, Columbus, OH.
Purpose: The purpose of the current study was to gain insight on augmentative and alternative communication (AAC) interface designs for children with cortical visual impairment (CVI). Children with CVI frequently require AAC and specific interface supports, and customization may be necessary to support access and use of speech-generating devices.
Method: A focus group methodology was selected to gain feedback from vision professionals on helpful AAC features for children with CVI.
Bioinspired Antiswelling Hydrogel Sensors with High Strength and Rapid Self-Recovery for Underwater Information Transmission.
ACS Appl Mater Interfaces
January 2025
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Hydrogel-based sensors typically demonstrate conspicuous swelling behavior in aqueous environments, which can severely compromise the mechanical integrity and distort sensing signals, thereby considerably constraining their widespread applicability. Drawing inspiration from the multilevel heterogeneous structures in biological tissues, an antiswelling hydrogel sensor endowed with high strength, rapid self-recovery, and low swelling ratio was fabricated through a water-induced phase separation and coordination cross-linking strategy. A dense heterogeneous architecture was developed by the integration of "rigid" quadridentate carboxyl-Zr coordination bonds and "soft" hydrophobic unit-rich regions featuring π-π stacking and cation-π interactions into the hydrogels.
View Article and Find Full Text PDFThe high-osmolarity glycerol (HOG) pathway in .
mBio
January 2025
University of Angers, Brest University, IRF, SFR ICAT, Angers, France.
The emerging fungal pathogen is known for its strong skin tropism and resilience against antifungal and disinfection treatment, posing a significant challenge for healthcare units. Although efforts to identify the effectors of its unique pathogenic behavior have been insightful, the role of the high-osmolarity glycerol (HOG) pathway in this context remains unexplored. The study by Shivarathri and co-workers (R.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!