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Comprehensive analysis of ESCRT transcriptome-associated signatures and identification of the regulatory role of LMO7-AS1 in osteosarcoma.
Cancer Cell Int
January 2025
Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Osteosarcoma (OS) is a commonly observed malignant tumor in orthopedics that has a very poor prognosis. The endosomal sorting complex required for transport (ESCRT) is important for the development and progression of cancer and may be a significant target for cancer therapy. First, we built a prognostic signature using 7 ESCRT-related genes (ERGs) to predict OS patient prognosis.
View Article and Find Full Text PDFAPOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease.
J Neuroinflammation
January 2025
Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, 85013, USA.
The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is linked to demyelination and cognitive decline. However, its effects on the lipid transporters apolipoprotein E (ApoE) and fatty acid-binding protein 7 (Fabp7), which are crucial for the maintenance of myelin in white matter (WM) during the progression of AD remain underexplored. To evaluate the effects of APOEε4 on ApoE, Fabp7 and myelin in the WM of the frontal cortex (FC), we examined individuals carrying one ε4 allele that came to autopsy with a premortem clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI) and mild to moderate AD compared with non-carrier counterparts.
View Article and Find Full Text PDFSeason of conception and risk of hypertensive disorder during pregnancy.
BMC Pregnancy Childbirth
January 2025
National Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan University, No. 17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China.
Background: Hypertensive Disorder during Pregnancy (HDP) is the most prevalent obstetric conditions in maternal health, but the etiology of most cases remains unexplained. Seasonal variations in the conception of HDP may offer insights into the potential seasonal-specific risk factors.
Methods: Data were sourced from the China's National Maternal Near Miss Surveillance System (NMNMSS) between January 1, 2012, and December 31, 2021.
Impact of maternal age on birth weight-related adverse outcomes in newborns: a retrospective study in south-central China.
BMC Pregnancy Childbirth
January 2025
Department of Child Healthcare, Changsha City Maternal and Child Health Care Hospital, Chengnan East Road No.416, Yuhua District, Changsha, 410007, China.
Background: Birth weight is a critical indicator for assessing fetal development and newborn health status. This study aimed to examine both linear and nonlinear associations between maternal age and birth weight and their related adverse outcomes.
Methods: 15,923 delivery data from 2018 to 2021 for pregnant women from the Changsha Maternal and Child Health Care Hospital were reviewed by a retrospective study.
Experiences of adults with type 2 diabetes mellitus with low socioeconomic status: a qualitative study.
BMC Public Health
January 2025
Faculty of Health Sciences, Department of Internal Medicine Nursing, Sakarya University, Sakarya, 54050, Turkey.
Background: Adults with diabetes encounter various challenges related to managing their condition. In this study, we explored the experiences of adults with type 2 diabetes mellitus with low socioeconomic status in Türkiye.
Methods: This study was conducted as a phenomenological qualitative research.
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