A war between the Ethiopian federal government and Tigray regional government broke out on November 4, 2020 and is still ongoing. Regardless of the cause of the war, the civilian populations, who have no agency in the fighting, have often been at the receiving end of atrocities. Eight months into the war, a siege was imposed in Tigray, barring the entry of all forms of humanitarian aid, including food and medicines. As a result, civilians who survived hostilities are dying from hunger and diseases due to the blockade which has been put in place. One particular group of patients whose survival is at stake encompasses those with end-stage kidney disease, including kidney transplant recipients. The leading challenges of providing care to this group of patients amidst war and blockade include a barely functioning dialysis service, due to dwindling supplies, lack of access to the country's kidney transplant center in Addis Ababa, and severe shortages of immunosuppressive medications. To put this into perspective, we report on a 45-year-old female recipient of a kidney transplant at St. Paul's Hospital in Addis Ababa who succumbed in the besieged Tigray region as a result of lack of access to her transplant medicines. We urgently call upon the international nephrology societies and kidney transplant associations to advocate access to immunosuppressive medications for kidney transplant recipients in Tigray, Northern Ethiopia, to avert additional catastrophic events like the reported one.
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http://dx.doi.org/10.1007/s40620-022-01380-3 | DOI Listing |
Int Urol Nephrol
January 2025
Nephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Introduction: Kidney transplantation is the preferred treatment for end-stage kidney disease (ESKD), enhancing survival and quality of life. However, kidney transplant recipients (KTRs) are at high risk for bone disorders, particularly low bone turnover disease, which increases fracture risk. Teriparatide, an anabolic agent, may provide a beneficial treatment option for these patients.
View Article and Find Full Text PDFSci Rep
January 2025
Renal Division, Department of Medicine, Universidade Federal de São Paulo, Rua Pedro de Toledo, 781, São Paulo, SP, 04039-032, Brazil.
Partial stenosis of the renal artery causes renovascular hypertension (RVH) and is accompanied by chronic renal ischemia, resulting in irreversible kidney damage. Revascularization constitutes the most efficient therapy for normalizing blood pressure (BP) and has significant benefits for renal function; however, the tissue damage caused by chronic hypoxia is not fully reversed. Mesenchymal stem cells (MSCs) have produced discrete results in minimizing RVH and renal tissue and functional improvements since the obstruction persists.
View Article and Find Full Text PDFAm J Transplant
February 2025
Division of Immunology and Organ Transplantation, McGovern Medical School at the University of Texas Health Sciences Center, Houston, Texas, USA.
Nephrol Dial Transplant
January 2025
Clinica Medica, University Milano-Bicocca and University of Milano-Bicocca, Milan, Italy.
The autonomic nervous system plays a crucial role in regulating physiological processes and maintaining homeostasis through its two branches: the sympathetic nervous system (SNS) and the parasympathetic nervous system. Dysregulation of the autonomic system, characterized by increased sympathetic activity and reduced parasympathetic tone, is a common feature in chronic kidney disease (CKD) and cardiovascular disease. This imbalance contributes to a pro-inflammatory state, exacerbating disease progression and increasing the risk for cardiovascular events.
View Article and Find Full Text PDFNephrol Dial Transplant
January 2025
Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan.
Background And Hypothesis: It is unclear if low birth weight (LBW), preterm birth and small for gestational age (SGA) could synergistically cause chronic kidney disease (CKD) and end-stage kidney disease (ESKD). This cohort study was conducted to examine their individual and combined impacts on the development of CKD and ESKD in childhood.
Methods: From the Taiwan Maternal and Child Health Database, we identified 1 477 128 newborns born between January 1, 2009, and December 31, 2016.
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