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Urine proteomics defines an immune checkpoint-associated nephritis signature.
J Immunother Cancer
January 2025
Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Immune checkpoint inhibitor (ICI) therapy is a cornerstone treatment for many cancers, but it can induce severe immunotoxicity, including acute interstitial nephritis (AIN). Currently, kidney biopsy is required to differentiate ICI-AIN from other causes of acute kidney injury (AKI). However, this invasive approach can lead to morbidity, delayed glucocorticoid treatment for patients with AIN, and unnecessarily prolonged suspension of ICI therapy in non-AIN patients.
View Article and Find Full Text PDFLow hysteresis and high sensitivity TPU/carbonized wood cellulose sponge sensors for monitoring dynamic pulses.
Int J Biol Macromol
January 2025
School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.
The importance of continuous and reliable pulse wave monitoring is constantly being increased in health signal monitoring and disease diagnoses. Flexible pressure sensors with high sensitivity, low hysteresis and fast response time are an effective means for monitoring pulses. Herein, a special wave-shaped layered porous structure of carbonized wood cellulose sponge (CWCS) was constructed based on natural wood (NW).
View Article and Find Full Text PDFA novel genetically encoded indicator for deciphering cytosolic and mitochondrial nitric oxide in live cells.
Biochem Biophys Res Commun
January 2025
Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address:
Nitric oxide (NO) has been highlighted as a key gaseous signaling molecule in the body, playing a central role in various physiological and pathological processes. However, a comprehensive analysis of NO metabolism dynamics in living cells remains a significant challenge. To address this, we have developed and characterized a novel genetically encoded NO fluorescence sensor, GefiNO, to investigate NO metabolism dynamics in living cells and subcellular organelles.
View Article and Find Full Text PDFHow do trees fail in intraspecific competition? A test for the roles of non-structural carbohydrates and stoichiometries in Pinus massoniana.
Plant Physiol Biochem
January 2025
College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address:
Competition is ubiquitous and an important driver of tree mortality. Non-structural carbohydrates (NSCs, including soluble sugars and starch) and C-N-P stoichiometries are affected by the competitive status of trees and, in turn, physiologically determine tree growth and survival in competition. However, the physiological mechanisms behind tree mortality caused by intraspecific competition remain unclear.
View Article and Find Full Text PDFHeterogeneity in Fluorescence-Stained Sperm Membrane Patterns and Their Dynamic Changes Towards Fertilization in Mice.
Front Biosci (Landmark Ed)
January 2025
Graduate School of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 400-8510 Kofu, Japan.
Background: Sperm represent a heterogeneous population crucial for male reproductive success. Additionally, sperm undergo dynamic changes during maturation and capacitation. Despite these well-established processes, the complex nature of sperm heterogeneity and membrane dynamics remains elusive.
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