Copper-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes to construct SCF-containing dioxodibenzothiazepines.

Chem Commun (Camb)

College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China.

Published: August 2022

A mild and efficient Cu-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes with readily available and stable AgSCF as the trifluoromethylthiolating reagent has been disclosed. This transformation provides an opportunity to construct a series of potential medicinally valuable trifluoromethylthio-substituted dioxodibenzothiazepines with wide functional group compatibility. This protocol opens up a new avenue for the construction of useful trifluoromethylthiolated seven-membered N-heterocycles.

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http://dx.doi.org/10.1039/d2cc02171dDOI Listing

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