A mild and efficient Cu-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes with readily available and stable AgSCF as the trifluoromethylthiolating reagent has been disclosed. This transformation provides an opportunity to construct a series of potential medicinally valuable trifluoromethylthio-substituted dioxodibenzothiazepines with wide functional group compatibility. This protocol opens up a new avenue for the construction of useful trifluoromethylthiolated seven-membered N-heterocycles.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d2cc02171d | DOI Listing |
Chem Commun (Camb)
August 2022
College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China.
A mild and efficient Cu-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes with readily available and stable AgSCF as the trifluoromethylthiolating reagent has been disclosed. This transformation provides an opportunity to construct a series of potential medicinally valuable trifluoromethylthio-substituted dioxodibenzothiazepines with wide functional group compatibility. This protocol opens up a new avenue for the construction of useful trifluoromethylthiolated seven-membered N-heterocycles.
View Article and Find Full Text PDFOrg Lett
June 2021
Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu 41566, Republic of Korea.
A new and efficient cascade electrophilic trifluoromethylthiolation/radical rearrangement reaction of ketoximes is reported using -trifluoromethylthio-dibenzenesulfonimide as the SCF source without any additives. This simple one-pot reaction provides the corresponding -trifluoromethanesulfinyl ketimine products in good yields with high selectivity under mild reaction conditions.
View Article and Find Full Text PDFOrg Lett
August 2015
†State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
A AgSCF3-mediated radical cascade cyclization/trifluoromethylthiolation of 1,6-enynes triggered by a C-C triple bond is developed. This protocol also provides another opportunity to construct a valuable trifluoromethylthio-substituted polycyclic fluorene system through the formations of one C-SCF3 bond and two C-C bonds in a single step.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!