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Behavioral and neural effects of temporoparietal high-definition transcranial direct current stimulation in logopenic variant primary progressive aphasia: a preliminary study.
Front Psychol
February 2025
Neurology, Medical College of Wisconsin, Milwaukee, WI, United States.
Background: High-definition-tDCS (HD-tDCS) is a recent technology that allows for localized cortical stimulation, but has not yet been investigated as an augmentative therapy while targeting the left temporoparietal cortex in logopenic variant PPA (lvPPA). The changes in neuronal oscillatory patterns and resting-state functional connectivity in response to HD-tDCS also remains poorly understood.
Objective: We sought to investigate the effects of HD-tDCS with phonologic-based language training on language, cognition, and resting-state functional connectivity in lvPPA.
Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).
Commun Biol
March 2025
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Física, and CONICET - Universidad de Buenos Aires, Instituto de Física Aplicada e Interdisciplinaria (INFINA), Buenos Aires, Argentina.
The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dimethyltryptamine (DMT), a short-acting psychedelic. To capture its transient effects, we parametrize the proximity to a global bifurcation using a pharmacokinetic equation.
View Article and Find Full Text PDFHow much data do you need? An analysis of pelvic multi-organ segmentation in a limited data context.
Phys Eng Sci Med
March 2025
Australian E-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Surgical Treatment and Rehabilitation Service, 296 Herston Road, Brisbane, QLD, 4029, Australia.
Training deep learning models generally requires large, costly datasets which can limit their application towards in-house segmentation tasks. This study investigates the trade-off in dataset size within the context of pelvic multi-organ MR segmentation where we evaluate the performance of nnU-Net, a well-known segmentation model, under conditions of limited domain and data availability. 12 participants undergoing treatment on an Elekta Unity were recruited, acquiring 58 MR images, with 4 participants (12 images) withheld for testing.
View Article and Find Full Text PDFNormalization of the percentage of signal recovery derived from dynamic susceptibility contrast perfusion MRI in brain tumors.
Neuroradiology
March 2025
UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California Los Angeles, Los Angeles, CA, USA.
The universalizability of the metric percentage of signal recovery (PSR) derived from dynamic susceptibility contrast (DSC) perfusion MRI is limited by its dependency of acquisition parameters. In this technical assessment, we tested different reference tissues for PSR normalization and found the normal-appearing white matter (NAWM) to have the least inter-patient variability when using a fixed PSR-optimized protocol. A logarithmic normalization using NAWM improved the consistency of PSR values when a cohort of brain tumor patients was analyzed by synthetically changing acquisition parameters (while keeping the protocol uniform within the cohort).
View Article and Find Full Text PDFMyocardial T1 Mapping, Left Ventricular Parameters, and Cardiac Biomarkers in Wild-Type Transthyretin Amyloid Cardiomyopathy Before and After Tafamidis Treatment.
Circ Rep
March 2025
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan.
Background: To further elucidate the clinical implications of myocardial T1 mapping with cardiac magnetic resonance (CMR) in transthyretin amyloid cardiomyopathy (ATTR-CM), we investigated the relationships of native myocardial T1 value (T1) and extracellular volume fraction (ECV) with left ventricular (LV) parameters and cardiac biomarkers in ATTR-CM patients before and after tafamidis treatment.
Methods And Results: We studied wild-type ATTR-CM patients who underwent baseline CMR with LV cine and T1 mapping techniques. T1 and ECV were derived from averaged values of base-to-apex LV myocardium.
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