AI Article Synopsis
- The text discusses the use of a genetic model organism for studying aging, focusing on its contributions to understanding neurodegeneration and DNA repair mechanisms.
- It highlights that, despite its usefulness in aging research, this organism has not been widely used to explore DNA repair and genomic instability, which are crucial in aging and rare neurological disorders.
- The article emphasizes the importance of DNA repair pathways and their effects on aging-related issues like mitochondrial dysfunction and telomere maintenance, proposing that this organism is ideal for studying the relationship between DNA repair and neurodegeneration.
Article Abstract
Since its introduction as a genetic model organism, has yielded insights into the causes of aging. In addition, it has provided a molecular understanding of mechanisms of neurodegeneration, one of the devastating effects of aging. However, has been less popular as an animal model to investigate DNA repair and genomic instability, which is a major hallmark of aging and also a cause of many rare neurological disorders. This article provides an overview of DNA repair pathways in and the impact of DNA repair on aging hallmarks, such as mitochondrial dysfunction, telomere maintenance, and autophagy. In addition, we discuss how the combination of biological characteristics, new technical tools, and the potential of following precise phenotypic assays through a natural life-course make an ideal model organism to study how DNA repair impact neurodegeneration in models of common age-related neurodegenerative diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261396 | PMC |
| http://dx.doi.org/10.3389/fragi.2022.916118 | DOI Listing |
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