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Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights.
BMC Psychiatry
December 2024
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere, Finland.
Background: Autism spectrum disorder (ASD) is a partially heritable neurodevelopmental trait, and people with ASD may also have other co-occurring trait such as ADHD, anxiety disorders, depression, mental health issues, learning difficulty, physical health traits and communication challenges. The concomitant development of ASD and other neurological traits is assumed to result from a complex interplay between genetics and the environment. However, only a limited number of studies have performed multivariate genome-wide association studies (GWAS) for ASD.
View Article and Find Full Text PDFThis report describes a case of disseminated proliferative mesocestoidosis in a French bulldog from Aichi, Japan. In July 2023, the dog presented with chronic enteritis, and histological examination of the endoscopic biopsy specimen revealed parasites with suckers. Three months later, numerous tetrathyridia were detected in the inguinal mass.
View Article and Find Full Text PDFStrain-specific differences in reovirus infection of murine macrophages segregate with polymorphisms in viral outer-capsid protein σ3.
J Virol
November 2024
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mammalian orthoreovirus (reovirus) strains type 1 Lang (T1L) and type 3 Dearing-RV (T3D-RV) infect the intestine in mice but differ in the induction of inflammatory responses. T1L infection is associated with the blockade of oral immunological tolerance to newly introduced dietary antigens, whereas T3D-RV is not. T1L infection leads to an increase in infiltrating phagocytes, including macrophages, in gut-associated lymphoid tissues that are not observed in T3D-RV infection.
View Article and Find Full Text PDFFirst insight of the genome-wide association study and genomic prediction into enteritis disease () resistance trait in the lined seahorse ().
Front Immunol
October 2024
Key Laboratory of Inland Saline-alkaline Aquaculture, Ministry of Agriculture and Rural Affairs, Shanghai, China.
Article Synopsis
- Enteritis, caused by Vibrio harveyi, is a serious disease affecting seahorse aquaculture, prompting a study on the genetic factors behind disease resistance.
- The research involved a genome-wide association study (GWAS) that identified 10 significant SNPs linked to resistance, revealing a heritability estimate of 0.10 for the trait.
- Results indicated that genomic selection (GS) showed potential for breeding disease-resistant seahorses, with the BayesC model performing best in predictive accuracy compared to other selection methods.
Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with bacterial diarrhea susceptibility in Barki lambs.
BMC Vet Res
October 2024
Department of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Cairo, Egypt.
Article Synopsis
- - Diarrhea in lambs, a critical health issue in ovine medicine, leads to substantial economic losses due to high mortality rates and treatment costs, with Salmonella and enterotoxigenic E. coli as primary causes.
- - The study aimed to analyze genetic variations, gene expression, and biomarkers related to inflammation and oxidative stress in lambs with diarrhea, alongside identifying different strains of the pathogens involved.
- - Results indicated the presence of specific virulence genes associated with E. coli and Salmonella in all diarrheic lambs, as well as identified genetic markers related to immune response, antioxidant activity, and gastrointestinal health.
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