AI Article Synopsis
- * Covalently closed circular RNAs (circRNAs) have been recognized as important regulators in various cancers, including GC, and show altered patterns in GC that contribute to its invasion and spread.
- * The paper aims to explore the roles of circRNAs in GC metastasis and drug resistance, discussing their mechanisms and potential as targets for future therapies.
Article Abstract
Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields meaningful insights into potential biomarkers and therapeutic targets. Covalently closed circular RNAs (circRNAs) have emerged as crucial regulators in diverse human cancers including GC. Furthermore, accumulating evidence has demonstrated that circRNAs exhibit the dysregulated patterns in GC and have emerged as crucial regulators in GC invasion and metastasis. However, systematic knowledge regarding the involvement of circRNAs in metastatic GC remains obscure. In this review, we outline the functional circRNAs related to GC metastasis and drug resistance and discuss their underlying mechanisms, providing a comprehensive delineation of circRNA functions on metastatic GC and shedding new light on future therapeutic interventions for GC metastases.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277821 | PMC |
| http://dx.doi.org/10.1186/s13046-022-02432-z | DOI Listing |
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