AI Article Synopsis
- Deucravacitinib, an oral treatment for moderate to severe plaque psoriasis, showed significantly better efficacy compared to placebo and apremilast in the phase 3 POETYK PSO-1 trial.
- Response rates at week 16 indicated that 58.4% of participants achieved a 75% reduction in psoriasis severity (PASI 75) with deucravacitinib, compared to only 12.7% with placebo and 35.1% with apremilast.
- The treatment was well tolerated, with adverse event rates similar to those seen with placebo and apremilast, although the study's one-year duration and limited racial diversity are noted as limitations.
Article Abstract
Background: Effective, well-tolerated oral psoriasis treatments are needed.
Objective: To compare the efficacy and safety of deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, versus placebo and apremilast in adults with moderate to severe plaque psoriasis.
Methods: Participants were randomized 2:1:1 to deucravacitinib 6 mg every day (n = 332), placebo (n = 166), or apremilast 30 mg twice a day (n = 168) in the 52-week, double-blinded, phase 3 POETYK PSO-1 trial (NCT03624127). Coprimary end points included response rates for ≥75% reduction from baseline in Psoriasis Area and Severity Index (PASI 75) and static Physician's Global Assessment score of 0 or 1 (sPGA 0/1) with deucravacitinib versus placebo at week 16.
Results: At week 16, response rates were significantly higher with deucravacitinib versus placebo or apremilast for PASI 75 (194 [58.4%] vs 21 [12.7%] vs 59 [35.1%]; P < .0001) and sPGA 0/1 (178 [53.6%] vs 12 [7.2%] vs 54 [32.1%]; P < .0001). Efficacy improved beyond week 16 and was maintained through week 52. Adverse event rates with deucravacitinib were similar to those with placebo and apremilast.
Limitations: One-year duration, limited racial diversity.
Conclusion: Deucravacitinib was superior to placebo and apremilast across multiple efficacy end points and was well tolerated in moderate to severe plaque psoriasis.
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| http://dx.doi.org/10.1016/j.jaad.2022.07.002 | DOI Listing |
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