Highly efficient amino-functionalized aluminum-based metal organic frameworks mesoporous nanorods for selective extraction of hydrocortisone in pharmaceutical wastewater.

J Pharm Biomed Anal

Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China; Department of Pharmaceutical Analysis, College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China. Electronic address:

Published: September 2022

AI Article Synopsis

  • Hydrocortisone (HC) is a steroid hormone drug that poses environmental risks as it often contaminates pharmaceutical wastewater, threatening human health and ecosystem sustainability.
  • A new adsorbent system called Al-MOFs@NH, made from amino-functionalized aluminum-based metal-organic frameworks, was developed to effectively capture HC due to its large surface area and stable structure.
  • The Al-MOFs@NH system, combined with HPLC, shows high selectivity, a low limit of detection, and reliable recovery rates for HC, making it a promising solution for analyzing and removing steroid hormone pollutants from wastewater.

Article Abstract

Hydrocortisone (HC), as a common steroid hormone drug, is also one of the key intermediates involved in the synthesis of multiple steroid hormone drugs. Residual HC in pharmaceutical wastewater frequently pollutes environmental water as steroid hormone contaminant and possesses great threat to human health as well as sustainable development of the ecosystem. Herein, in order to develop a highly efficient adsorbent system for selective enrichment and detection of HC in pharmaceutical wastewater, a novel amino-functionalized aluminum-based metal organic frameworks (Al-MOFs@NH) mesoporous nanorod is fabricated, in which 2-aminoterephthalic acid plays a dual role as organic linker and functional modification unit. The resultant Al-MOFs@NH not only exhibits stable mesoporous structure but also has large specific surface area (849.76 m g) and plentiful binding sites, which significantly increases the adsorption capacity for HC. Under the promotion of hydrogen bonding and hydrophobic interaction together, Al-MOFs@NH possesses high adsorption capacity (218.53 mg g) for HC, as well as shows satisfactory selectivity for HC and other steroid hormones. Moreover, a method using Al-MOFs@NH as solid phase extraction adsorbents combined with high performance liquid chromatography (HPLC) has been developed to specifically enrich and detect trace amount of HC in pharmaceutical wastewater. The developed method has a low limit of detection (LOD) (0.5×10 μg mL) and shows satisfactory recoveries for HC (75.9%-102.5%) with an acceptable relative standard deviation (RSD). These results demonstrate that the facile one-step preparation and excellent adsorption capacity makes Al-MOFs@NH attractive to capture and remove environmental steroid hormone pollutants. More importantly, the method proposed in this work is expected to provide a prospective solution for analysis of strong bioactive contaminants in pharmaceutical wastewater.

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Source
http://dx.doi.org/10.1016/j.jpba.2022.114933DOI Listing

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