AI Article Synopsis
- The study focuses on plants from the Hyptidinae subtribe in the Lamiaceae family, known for producing bioactive molecules that could be potential drug candidates.* -
- Researchers isolated and chemically characterized four diterpenes (Pomiferin D, Salviol, Pomiferin E, and 2α-hydroxysugiol) along with two phenolic compounds (rosmarinic and caffeic acids) using NMR techniques.* -
- The biological activity of the isolated compounds was tested, resulting in certain minimal inhibitory concentrations (MIC), with varying levels of effectiveness against specific targets, but some compounds showed no significant activity at the tested concentrations.*
Article Abstract
Plants of Hyptidinae subtribe (Lamiaceae - family), as , are a source of bioactive molecules. In the search for new drug candidates, we perform chemical characterization of diterpenes isolated from the aerial parts of was carried out with uni- and bidimensional NMR spectral data, and evaluate through the construction of a predictive model followed by testing and . Resulted in the isolation of four components: Pomiferin D (1), Salviol (2), Pomiferin E (3) and 2α-hydroxysugiol (4), as well as two phenolic compounds, rosmarinic and caffeic acids. model identified 48 diterpenes likely to have biological activity against . The diterpenes isolated were tested against demonstrating MIC = 125 µM for 4 and 1, while 2 and 3 -MIC = 250 µM. These compounds did not show biological activity at these concentrations for .
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| http://dx.doi.org/10.1080/14786419.2022.2096604 | DOI Listing |
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