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Clinical, Morphologic, and Genomic Differences in Deep Penetrating Nevi and Deep Penetrating Nevus-like Melanomas.
Mod Pathol
January 2025
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address:
Deep penetrating nevi (DPNs) are characterized by activating mutations in the MAP kinase and Wnt/beta-catenin pathways that result in large melanocytes with increased nuclear atypia, cytoplasmic pigmentation, and often mitotic activity. Together with a lack of maturation, this constellation of findings creates challenges for pathologists to distinguish deep penetrating nevus (DPN) from DPN-like melanoma. To assess the utility of next generation sequencing (NGS) in resolving this diagnostic dilemma, we performed NGS studies on 35 lesions including 24 DPNs and 11 DPN-like melanomas to characterize the specific genomic differences between the two groups and elucidate the genetic events involved in malignant transformation of DPNs.
View Article and Find Full Text PDFNeuromorphic-enabled video-activated cell sorting.
Nat Commun
December 2024
State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China.
Imaging flow cytometry allows image-activated cell sorting (IACS) with enhanced feature dimensions in cellular morphology, structure, and composition. However, existing IACS frameworks suffer from the challenges of 3D information loss and processing latency dilemma in real-time sorting operation. Herein, we establish a neuromorphic-enabled video-activated cell sorter (NEVACS) framework, designed to achieve high-dimensional spatiotemporal characterization content alongside high-throughput sorting of particles in wide field of view.
View Article and Find Full Text PDFHarnessing opportunity cost salience for effortless self-control.
Curr Opin Psychol
February 2025
Department of Marketing, University of Groningen, the Netherlands.
Traditional psychological models characterize self-control as an inherently effortful process, relying on deliberate and cognitively demanding strategies to resist impulsive temptations. Drawing on behavioral economics literature, we investigate opportunity cost salience as an effective intervention to enhance self-control with minimal effort. Specifically, we demonstrate that opportunity cost salience facilitates the intuitive detection of self-control conflicts and motivates the pursuit of valued long-term goals by altering the subjective value of present and future outcomes in self-control dilemmas.
View Article and Find Full Text PDFDevelopment and validation of situational judgement test for assessment of behavioural competencies required for effective medical practice in Nigeria.
BMC Med Educ
November 2024
Department of Community Medicine, College of Medicine, University of Nigeria, Enugu-Campus, Enugu, Nigeria.
Background: The personal qualities of health workers determine the way health services are provided to clients. Some key personal qualities (also called behavioural competencies) of physicians that contribute to quality healthcare delivery include ethical responsibility, empathy, patient-centeredness, diligence, good judgment, respectful, teamwork, team leadership/conflict management, ability to take correction and tolerance. In this study, we developed and validated clinical scenarios (dilemmas) for assessing priority behavioural competencies for medical practice in Nigeria.
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