AI Article Synopsis
- The study evaluates the effectiveness of plasma methylated septin 9 DNA as a biomarker for detecting colorectal cancer (CRC) and monitoring recurrence in Chinese patients.
- The research involved 616 CRC patients and 122 healthy individuals, measuring various markers and assessing their diagnostic value through sensitivity, specificity, and ROC curves.
- Results indicated that methylated septin 9 outperformed traditional markers CEA and CA19-9 in sensitivity and specificity, and its positivity was closely linked to cancer stage and recurrence, supporting its potential as a reliable CRC biomarker.
Article Abstract
Purpose: The clinical utility of plasma methylated septin 9 () DNA in screening and recurrence monitoring for colorectal cancer (CRC) is highly promising. The present study was performed to determine the diagnostic value of in CRC detection and recurrence monitoring in Chinese patients.
Methods: Overall, 616 patients newly diagnosed with CRC and 122 individuals with no evidence of disease were recruited from October 1, 2019, to May 31, 2021, at Fujian Medical University Union Hospital. Plasma and serum samples were collected for analyzing , carcinoembryonic antigen (CEA), and carbohydrate antigen-19-9 (CA19-9). Data on clinicopathological characteristics were collected and analyzed. Sensitivity and specificity were calculated to evaluate the diagnostic potential of each marker; the receiver operating characteristic (ROC) curve was applied for the assessment of diagnostic value, and comparisons among , CEA, CA19-9, and their combination were assessed via ROC curves.
Results: achieved an overall sensitivity and specificity of 72.94% and 81.97%, respectively, with an area under the curve (AUC) value of 0.826, which were higher than those of CEA (sensitivity: 43.96%; specificity: 96.72%; AUC: 0.789) and CA19-9 (sensitivity: 14.99%; specificity: 96.61%; AUC: 0.590). The combination of , CEA, and CA19-9 further improved sensitivity, specificity, and AUC value (sensitivity: 78.43%; specificity: 86.07%; AUC: 0.878), respectively. Notably, the positivity rate was significantly associated with TNM stage, T stage, N stage, tumor size, vascular invasion, and nerve invasion among patients with CRC. A 100% correlation was observed between the positive results of the test and recurrence or metastasis in patients after therapeutic intervention.
Conclusion: Our findings suggest that may represent a potential biomarker for the diagnosis and prognosis of CRC compared with CEA and CA19-9. Postoperative status may represent the first noninvasive marker of CRC recurrence or metastasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271001 | PMC |
| http://dx.doi.org/10.1155/2022/7087885 | DOI Listing |
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