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Laryngeal histoplasmosis is a very rare cause of laryngitis which is encountered usually in the immunosuppressed states but can also occur in immunologically intact status. We report a rare case of laryngeal histoplasmosis in a man in his 60s, a chronic smoker who presented with a history of progressive hoarseness for 3 months. The glottic growth was biopsied. The rarity of diagnosis was aided by histopathological examination of the tissue, which revealed histoplasmosis. Management was done with intravenous liposomal amphotericin B and oral itraconazole with complete resolution of symptoms.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274538 | PMC |
http://dx.doi.org/10.1136/bcr-2022-248738 | DOI Listing |
Indian J Otolaryngol Head Neck Surg
October 2024
Department of Otorhinolaryngology, Mahatma Gandhi Medical college, Jaipur, Rajasthan, 302033 India.
Granulomatous lesions, though rare, can affect diverse body regions, including the larynx, presenting diagnostic challenges. In India, where malignancy and tuberculosis prevail, fungal infections are often overlooked. We present a case of 34 year old male with complaint of change in voice which was approached as malignancy but later turned out to be histoplasmosis on histopathology.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
December 2022
Master of Surgery (Otorhinolaryngology), Dr K.C. Kasliwal's E.N.T. Centre, Mani Mahal, Paanch Batti, Opposite Rajmandir Cinema, Jaipur, 302001 India.
Histoplasmosis of Larynx is a very rare anomaly and is usually not seen in an immunocompetent indivual. We present to you a case of 50 year old male, who came to our OPD with complaint of hoarseness of voice. Due to its high probability of mimicking the symptoms of laryngeal carcinoma, differential diagnosis of fungal laryngitis should always be kept in mind.
View Article and Find Full Text PDFTurk Patoloji Derg
May 2023
Department of Pathology, Tata Memorial Center, MUMBAI, INDIA.
Objective: Histoplasmosis is a systemic, deep mycotic infection caused by Histoplasma capsulatum. Disseminated histoplasmosis (DH) is synonymous with HIV seropositive immunocompromised individuals; however, isolated histoplasmosis involving the head and neck mucosal sites mimicking malignancy is a clinical predicament. The result, in a superficial biopsy with marked pseudoepitheliomatous hyperplasia (PEH), in a tertiary care cancer center where the number of squamous carcinomas far outnumber the infectious diseases, could be catastrophic.
View Article and Find Full Text PDFBMJ Case Rep
July 2022
Pathology, Army Hospital Research and Referral, New Delhi, Delhi, India.
Laryngeal histoplasmosis is a very rare cause of laryngitis which is encountered usually in the immunosuppressed states but can also occur in immunologically intact status. We report a rare case of laryngeal histoplasmosis in a man in his 60s, a chronic smoker who presented with a history of progressive hoarseness for 3 months. The glottic growth was biopsied.
View Article and Find Full Text PDFAnn Otol Rhinol Laryngol
March 2023
Section of Otolaryngology, Department of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Objectives: is a prevalent dimorphic fungus, reaching an exposure rate of 90% in endemic areas such as the Midwest and Central United States. We report an unusual presentation of dysphonia due to right vocal cord paralysis caused by mediastinal lymphadenopathy from histoplasmosis.
Methods: A 73-year-old male presented to an otolaryngology clinic with 4 months of hoarseness.
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