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Prospective associations between white matter hyperintensities and lower extremity function.
Neurology
April 2018
From Gerontopole of Toulouse (S.Y.M., P.d.S.B., Y.R., S.A., M.C., B.V.) and Department of Epidemiology and Public Health (S.A.), University Hospital of Toulouse (CHU-Toulouse); UMR INSERM 1027 (S.Y.M., P.d.S.B., Y.R., S.A., M.C., B.V.), University of Toulouse III, France; Department of Neurology (S.Y.M.), Ajou University School of Medicine, Kyungki-do, Republic of Korea; UPMC Univ Paris 06 (M.C.), UMR S 1127, ICM, Sorbonne Universités; Inserm (M.C.), U1127; CNRS (M.C.), UMR 7225; ICM (M.C.); Inria Paris-Rocquencourt (M.C.), Paris; UNATI (J.F.M.), Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette; and CATI Multicenter Neuroimaging Platform (A.B., L.F., J.F.M., M.C.), cati-neuroimaging.com, France.
Objective: To evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints.
Methods: We obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and from 358 adults over an average follow-up of 963 days. We evaluated LEF using the Short Physical Performance Battery (SPPB).
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