AI Article Synopsis
- Hyperchloremia, an imbalance of chloride levels in the body, may increase morbidity and mortality, particularly in critically ill patients, and this study explores its link to COVID-19 outcomes.
- The study aimed to see if a sodium-chloride difference of less than 31 mEq/L within 24-48 hours of COVID-19 admission predicts 28-day mortality and other complications like the need for mechanical ventilation and kidney issues.
- Results indicated that while a sodium-chloride difference below 31 mEq/L doesn't predict higher death or ventilation rates, it is linked to a greater risk of acute kidney injury and longer hospital stays for COVID-19 patients.
Article Abstract
Background: Hyperchloremia has been associated with a greater presence of morbidity and mortality, mainly described in critically ill patients, this may be relative and absolute, which could be reflected in the sodium-chloride difference.
Objective: The primary objective was to determine whether the sodium-chloride difference <31 mEq/L measured 24-48 hours after admission is a predictor of 28-day mortality in patients with COVID-19, and as secondary objectives to identify whether it is associated with higher requirement for invasive mechanical ventilation, presence of acute kidney injury and longer hospital stay.
Material And Methods: Retrospective, descriptive and analytical longitudinal cohort study, was done including all consecutive patients older than 16 years of any gender, admitted to the UMAE from March 1, 2020 to March 2021, which present a diagnosis of COVID-19 with RT-PCR test for SARS-CoV-2 positive.
Results: A total of 722 patients were included, the difference sodium-chloride < 31 mEq/L is not associated with an increased risk of death at 28 days (p = 1.172, OR: 1.35; 95%CI, 0.87-2.08) or requirement of mechanical ventilation (p = 0.47, OR: 1.19; 95%CI, 0.76-1.86), but is associated with a higher risk of AKI (p < 0.05, OR: 2.04; 95%CI, 1.33- 3.14) and longer hospital stay (p < 0.05).
Conclusions: the sodium-chloride difference < 31 mEq/L in the first hours of admission is associated with a higher risk of presenting acute kidney injury during hospital stay in patients with COVID-19, as well as a longer hospital stay.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396010 | PMC |
Publication Analysis
Top Keywords
Similar Publications
[Multicenter retrospect analysis of early clinical features and analysis of risk factors on prognosis of elderly patients with severe burns].
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
March 2024
Department of Critical Care Medicine, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China.
To investigate the early clinical characteristics of elderly patients with severe burns and the risk factors on prognosis. This study was a retrospective case series study. Clinical data of 124 elderly patients with severe burns who met the inclusion criteria and were admitted to the 12 hospitals from January 2015 to December 2020 were collected, including 4 patients from the Fourth People's Hospital of Dalian, 5 patients from Fujian Medical University Union Hospital, 22 patients from Guangzhou Red Cross Hospital of Jinan University, 5 patients from Heilongjiang Provincial Hospital, 27 patients from the First Affiliated Hospital of Naval Medical University, 9 patients from the First Affiliated Hospital of Nanchang University, 10 patients from Affiliated Hospital of Nantong University, 9 patients from Tongren Hospital of Wuhan University & Wuhan Third Hospital, 12 patients from the 924 Hospital of PLA, 6 patients from Zhangjiagang First People's Hospital, 4 patients from Taizhou Hospital of Zhejiang Province, and 11 patients from Zhengzhou First People's Hospital.
View Article and Find Full Text PDFSources of personal PM exposure during pregnancy in the MADRES cohort.
J Expo Sci Environ Epidemiol
September 2024
Spatial Sciences Institute, University of Southern California, Los Angeles, CA, USA.
Background: Personal exposure to fine particulate matter (PM) is impacted by different sources each with different chemical composition. Determining these sources is important for reducing personal exposure and its health risks especially during pregnancy.
Objective: Identify main sources and their contributions to the personal PM exposure in 213 women in the 3rd trimester of pregnancy in Los Angeles, CA.
Nickel ion release and surface analyses on instrument fragments fractured beyond the apex: a laboratory investigation.
BMC Oral Health
September 2023
Department of Periodontology, Faculty of Dentistry, Eskisehir Osmangazi University, Eskisehir, 26040, Turkey.
Background: To analyse the changes in surface and nickel ion release characteristics of fractured root canal shaping instruments in a simulated body fluid environment.
Methods: A total of 54 new instruments were studied. The instrument groups consisted of five different NiTi alloys and a stainless-steel alloy.
Study protocol for the BUSCopan in LABor (BUSCLAB) study: A randomized placebo-controlled trial investigating the effect of butylscopolamine bromide to prevent prolonged labor.
PLoS One
November 2022
Division of Obstetrics and Gynecology, Department of Obstetrics, Oslo University Hospital, Oslo, Norway.
Article Synopsis
- First-time mothers often experience prolonged labor, which can affect about 20% of them and lead to negative birth outcomes; oxytocin is commonly used but has drawbacks.
- This study aims to determine if the antispasmodic drug butylscopolamine bromide (Buscopan®) can effectively shorten labor duration for first-time mothers who show signs of slow progress, as assessed by the World Health Organization partograph.
- Conducted at Oslo University Hospital, the trial will involve 250 women, comparing the effects of butylscopolamine to a placebo on labor duration, pain levels, need for oxytocin, delivery method, and overall maternal experience.
Reference intervals of 14 biochemical markers for children and adolescence in China: the PRINCE study.
Clin Chem Lab Med
September 2022
National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, P.R. China.
Objectives: The Pediatric Reference Intervals in China (PRINCE) was initiated to establish the reference intervals (RIs) of Chinese children, as well as to make it possible to compare the variability of biochemical markers among countries internationally.
Methods: Healthy participants, aged up to 20 years, from 11 provinces across China, were enrolled in PRINCE and according to a standard screening procedure, that included a questionnaire survey, physical examinations and laboratory tests. Fasting venous blood specimens were collected.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!