AI Article Synopsis
- Researchers have discovered a new method for chiral resolution using L-proline, allowing for the separation of R- and S-enantiomers of mandelic acid from a racemic mixture.
- This technique is innovative because it only requires changing the amounts of the resolving agent (stoichiometry) to achieve the separation.
- The success of this method is attributed to the formation of diverse cocrystal systems between the L-proline and the mandelic acid enantiomers, marking a significant advancement in the field.
Article Abstract
We present a thought-provoking development in chiral resolution. Using a resolving agent of a given handedness, L-proline, we show that both R- and S-enantiomers of mandelic acid can be resolved from a racemic mixture simply by varying the stoichiometry. We are the first to report this specific feature, achieved by the existence of stoichiometrically diverse cocrystal systems between R- and S-mandelic acid and L-proline.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2cc02942a | DOI Listing |
Publication Analysis
Top Keywords
mandelic acid
8
chiral resolution
8
l-proline resolution
4
resolution agent
4
agent target
4
target enantiomers
4
enantiomers mandelic
4
acid exciting
4
exciting case
4
case stoichiometry
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!