IS is an insertion sequence found in the complex, to which belongs, which can play a role in genome plasticity and in bacterial evolution. In this study, the abundance and location of IS on genomic data of French animal field strains were studied. A first analysis was performed on a panel of 81 strains that reflect the national population's genetic diversity. The results show that more than one-third of them are IS multicopy and that 10% have IS in a high copy number (more than 6 copies). Multicopy strains are those circulating in the regions where prevalence was above the national average. Further study of 93 such strains, with an IS copy number of 10-12, showed stability of IS copy number and genome location over time and between host species. The correlation between multicopy strains and high bovine tuberculosis (bTB) prevalence leads us to consider whether their epidemiological success could be partly due to genetic changes originated by IS transposition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260277 | PMC |
| http://dx.doi.org/10.3389/fmicb.2022.891902 | DOI Listing |
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