AI Article Synopsis
- The study investigates how vitamin D deficiency relates to renin-angiotensin-aldosterone levels in patients with essential hypertension in Urumqi, China.
- It involved 80 patients with hypertension and 76 healthy individuals, measuring various biochemical markers, including vitamin D levels and plasma renin activity.
- Results indicated that lower vitamin D levels were linked to higher renin levels and elevated systolic blood pressure, highlighting vitamin D's role in blood pressure regulation.
Article Abstract
Objective: The present study aims to investigate the relationship between vitamin D deficiency and renin-angiotensin-aldosterone levels in patients with essential hypertension.
Methods: The present study observed two groups of patients from Urumqi, Xinjiang, China, from April 2017 to March 2018. There were two subject groups: the hypertension group (80 patients with essential hypertension selected by random cluster sampling) and the control group (76 healthy adults). The 25-hydroxyvitamin D (25(OH)D or vitamin D) levels were measured through electrolytes; fasting blood glucose, blood lipids, and other biochemical indicators were detected using immune chemiluminescence; and plasma renin activity and angiotensin II concentrations were detected with radio-immunity.
Results: Comparison between the hypertension group and control group showed statistically significant differences in the systolic pressure and levels of 25(OH)D, renin, and triglycerides ( < 0.05). The correlation analysis showed that 25(OH)D was negatively correlated with renin ( = -0.185; =0.021) and positively correlated with systolic pressure ( = -0.105; =0.035). There were no statistically significant differences in diastolic pressure, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides between the two groups.
Conclusions: The results of the present study show that vitamin D deficiency is common in Urumqi, Xinjiang, China and vitamin D levels are negatively correlated with renin levels. Vitamin D plays an important role in regulating blood pressure by affecting renin levels through the renin-angiotensin-aldosterone system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205726 | PMC |
| http://dx.doi.org/10.1155/2022/8975396 | DOI Listing |
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