Adaptogenic and immunomodulatory activity of Virgozest - An ayurvedic proprietary formulation.

Introduction: (rejuvenator) or adaptogenic drugs have been proved to produce the complete potential to prevent diseases and degenerative changes that leads to diseases and promote longevity by providing strength and immunity. Virgozest is a poly-herbal formulation claimed to serve as adaptogenic, and immunomodulatory, as a health tonic, enriched with dry fruits, and ingredients containing natural supplements of Vitamin E and proteins.

Aim: To evaluate the adaptogenic activity and humoral immune activity of virgozest in Wistar albino rats.

Materials And Methods: Virgozest was evaluated for adaptogenic activity against swimming stress-induced changes and hypothermia in albino rats. The humoral immune activity of virgozest was evaluated against sheep red blood cells (SRBCs)-induced response in albino rats with the inclusion of cyclophosphamide as immune suppressant agent.

Results: In adaptogenic activity, virgozest (450 and 900 mg/kg) exhibited an increase in physical activity, decrease in stress-induced hypothermia, and serum cortisol level when compared to the stress control group of albino rats. In humoral immune activity, virgozest reversed the effects of cyclophosphamide-induced adverse changes on spleen and lymph node, and produced a significant increase in serum antibody titer in SRBCs-sensitized rats.

Conclusion: The present study concluded that virgozest has adaptogenic and humoral immune activity in Wistar albino rats, which may suggest the like properties of Ayurvedic formulation.