AI Article Synopsis

  • Lutein enhances skin color in chickens and exhibits antioxidant effects but its impact on lipid metabolism and oxidative stress is not fully understood.
  • A study found that chickens fed lutein showed increased fat yellowness and improved antioxidant enzyme activity in their livers compared to a control group.
  • RNA-seq and metabolomics analysis revealed significant changes in liver gene expression and plasma metabolites related to cytokine interactions and lipid metabolism, suggesting lutein could improve chicken health.

Article Abstract

Lutein can increase the body's skin color and has antioxidant potential. However, how it affects lipid metabolism and oxidative stress in chickens remains unknown. In this study, 74-day-old male chickens raised on feed supplemented with lutein had higher hip, back, breast, leg, shin and abdominal fat yellowness than the control group, and the livers of chickens in the lutein group had higher superoxide dismutase and glutathione peroxidase and lower malondialdehyde activities. To clarify the potential regulatory network regulated by lutein, we used RNA-seq and nontargeted metabolomics to detect changes in the male chicken liver and plasma, respectively. A total of 243 differentially expressed genes were significantly enriched in cytokine-cytokine receptor interaction signaling pathways, among others. A total of 237 significantly different metabolites were enriched in lysine biosynthesis and degradation and glycerophospholipid metabolism signaling pathways, among others. Finally, we comprehensively analyzed metabolome and transcriptome data and found that many differentially expressed genes and significantly different metabolites play crucial roles in lipid metabolism and oxidative stress. In summary, dietary lutein can improve male chicken skin yellowness and antioxidant indices and affect liver gene expression and plasma metabolites and may help improve the health of chickens.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260106PMC
http://dx.doi.org/10.3389/fvets.2022.906853DOI Listing

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