Treatment of ventriculitis caused by enterococci can be challenging, and antibiotic options are limited. We describe a case of device-related ventriculitis caused by vancomycin-resistant , refractory to initial antibiotics. Our management approach included intrathecal daptomycin. There were no attributable adverse events, and the patient remained infection-free following ventriculo-peritoneal shunt insertion and cessation of antibiotics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260094 | PMC |
| http://dx.doi.org/10.1099/acmi.0.000230 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Catheter-Associated Vancomycin-Resistant Enterococcus faecium Ventriculitis and Multidrug-Resistant Acinetobacter baumannii Pneumonia With Subsequent Acinetobacter Ventriculitis: A Case Report.
Cureus
November 2023
Neurosurgery, Desert Regional Medical Center, Palm Springs, USA.
Ventriculitis is associated with cerebrospinal fluid (CSF) shunts, and rare microorganisms associated with infection include vancomycin-resistant (VRE) and . Both organisms are known to cause nosocomial infections, and the emergence of multidrug-resistant (MDR) strains presents a treatment challenge. There is a lack of consensus on antimicrobial agent selection for ventriculitis involving VRE or MDR , which are life-threatening conditions.
View Article and Find Full Text PDFClinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations.
Antibiotics (Basel)
August 2023
Center for Antimicrobial Treatment Optimization Rotterdam (CATOR), 3015 GD Rotterdam, The Netherlands.
Article Synopsis
- - Drain-associated intracerebral infections are serious medical emergencies that are hard to treat because antibiotics struggle to reach the infection site, especially with the rise of multidrug-resistant bacteria, leading to potential use of off-label intrathecal (IT) antibiotics.
- - The study reviewed existing literature on IT dosing regimens and summarized clinical experiences with various antibiotics, showing how factors like the size of the ventricular system and CSF drainage volume influence treatment effectiveness.
- - While many side effects were noted for benzylpenicillin in earlier years, other antibiotics had mostly minor and reversible side effects when used properly, providing insight for choosing IT dosing strategies in cases of antibiotic resistance.
Intrathecal daptomycin use in a challenging case of ventriculitis.
Access Microbiol
April 2022
Barts Health NHS Trust, Royal London Hospital, Whitechapel Rd, London E1 1BB, UK.
Treatment of ventriculitis caused by enterococci can be challenging, and antibiotic options are limited. We describe a case of device-related ventriculitis caused by vancomycin-resistant , refractory to initial antibiotics. Our management approach included intrathecal daptomycin.
View Article and Find Full Text PDFTreatment Considerations for CNS Infections Caused by Vancomycin-Resistant : A Focused Review of Linezolid and Daptomycin.
Ann Pharmacother
December 2020
Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA.
Objective: To review the current literature describing pharmacology, pharmacokinetics/pharmacodynamics (PK/PD), efficacy, and safety of linezolid and daptomycin for the treatment of central nervous system (CNS) infections caused by vancomycin-resistant (VRE) .
Data Sources: A literature search of PubMed/MEDLINE databases was conducted (from 1950 to April 2020) utilizing the following key terms: , and .
Study Selection And Data Extraction: All relevant studies and case reports describing the treatment of VRE from the CNS with linezolid or daptomycin were included.
Intrathecal Antibacterial and Antifungal Therapies.
Clin Microbiol Rev
June 2020
Institute of Neuropathology, University Medical Center, Göttingen, Germany.
Intrathecal administration of anti-infectives is indicated in central nervous system infections by multiresistant pathogens when drugs that can reach adequate cerebrospinal fluid (CSF) concentrations by systemic therapy are not available. Antibiotics that readily pass the blood-brain and blood-CSF barriers and/or that have low toxicity allowing an increase in the daily dosage should not be used for intrathecal therapy. Intrathecal therapy is accompanied by systemic treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!