MMM - The molecular model of memory.

Identifying mechanisms underlying neurons ability to process information including acquisition, storage, and retrieval plays an important role in the understanding of the different types of memory, pathogenesis of many neurological diseases affecting memory and therapeutic target discovery. However, the traditional understanding of the mechanisms of memory associated with the electrical signals having a unique combination of frequency and amplitude does not answer the question how the memories can survive for life-long periods of time, while exposed to synaptic noise. Recent evidence suggests that, apart from neuronal circuits, a diversity of the molecular memory (MM) carriers, are essential for memory performance. The molecular model of memory (MMM) is proposed, according to which each item of incoming information (the elementary memory item - eMI) is encoded by both circuitries, with the unique for a given MI electrical parameters, and also the MM carriers, unique by its molecular composition. While operating as the carriers of incoming information, the MMs, are functioning within the neuron plasma membrane. Inactive (latent) initially, during acquisition each of the eMIs is activated to become a virtual copy of some real fact or events bygone. This activation is accompanied by the considerable remodeling of the MM molecule associated with the resonance effect.