AI Article Synopsis
- Effective connectivity between the cerebellum and primary motor cortex (M1) is important for motor skills and learning.
- Recent research suggests older adults may maintain or even enhance their ability to learn motor tasks, despite experiencing cerebellar atrophy.
- In this study, transcranial magnetic stimulation showed that older adults have stronger cerebellar inhibition compared to younger individuals, indicating changes in cerebellar-M1 connectivity with age, though the behavioral significance of this finding needs further exploration.
Article Abstract
Effective connectivity between the cerebellum and primary motor cortex (M1) is critical for motor learning and motor control. Despite evidence of cerebellar atrophy and declines in motor learning and motor control with advanced age, recent behavioral studies indicate that cerebellar-dependent motor learning processes are preserved or even enhanced in older adults. However, physiological evidence of heightened cerebellar excitability leading to strengthened cerebellar-M1 connectivity with advanced age is lacking. Here, we used transcranial magnetic stimulation to assess age-related effects on cerebellar inhibition, a measure of cerebellar-M1 connectivity, in 20 young and 19 older adults. We observed stronger cerebellar inhibition in older compared with young adults. The behavioral implications of strengthened cerebellar inhibition with advanced age found in this study remain to be determined.
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| http://dx.doi.org/10.1016/j.neurobiolaging.2022.04.016 | DOI Listing |
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