In a recent paper, Clavien et al. demonstrate the successful transplant of a sub-optimal donor liver using multi-day normothermic machine perfusion. This technological milestone opens up exciting new avenues for liver transplantation with the potential to ameliorate donor organ shortages and permit targeted therapeutic interventions.
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| http://dx.doi.org/10.1016/j.medj.2022.06.008 | DOI Listing |
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A case of frontal lobe seizures with 'dancing-like' semiology.
Eur J Neurol
September 2024
Neurophysiopathology and Movement Disorders Clinic, University of Messina, Messina, Italy.
Background And Purpose: 'Dancing-like' semiology is extremely rare and described in few case reports. It is characterized by rhythmic, oscillatory movements of the pelvis and/or limbs during which the subject appears to be dancing. It has been associated with both the frontal and temporal epileptic zone; however, the possible network involved in these fascinating seizures is unclear.
View Article and Find Full Text PDFVCA supercooling in a swine partial hindlimb model.
Sci Rep
June 2024
Shriners Children's Boston, Boston, MA, USA.
Vascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is of major importance in advancing this field. It would result in improved donor-recipient matching as well as the potential for ex vivo manipulation with gene and cell therapies.
View Article and Find Full Text PDFSuccessful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy.
EBioMedicine
September 2022
Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Division of Thoracic Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto Lung Transplant Program, Toronto, ON M5G 2C4, Canada. Electronic address:
Background: Cold static preservation (CSP) at higher temperatures (10°C) has been recently shown as an optimal strategy up to 24-36h of preservation. Here, we hypothesized that alternating 10°C static storage with cycles of normothermic ex vivo lung perfusion (EVLP) would provide conditions for cellular "recharge", allowing for multi-day lung preservation.
Methods: Donor lungs from male Yorkshire pigs were preserved using 10°C CSP with two cycles of 4h EVLP.
Multi-day perfusion of transplant organs: The how and the why.
Med
July 2022
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. Electronic address:
In a recent paper, Clavien et al. demonstrate the successful transplant of a sub-optimal donor liver using multi-day normothermic machine perfusion. This technological milestone opens up exciting new avenues for liver transplantation with the potential to ameliorate donor organ shortages and permit targeted therapeutic interventions.
View Article and Find Full Text PDFA Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues.
Front Pharmacol
December 2021
ETH Zürich, Department of Biosystems Science and Engineering, Basel, Switzerland.
Understanding the pharmacokinetic/pharmacodynamic (PK/PD)-relationship of a drug candidate is key to determine effective, yet safe treatment regimens for patients. However, current testing strategies are inefficient in characterizing responses to fluctuating drug concentrations during multi-day treatment cycles. Methods based on animal models are resource-intensive and require time, while traditional cell-culturing methods usually do not provide temporally-resolved information on the effects of -like drug exposure scenarios.
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