Topical Wound Therapy Products With Ionic Silver: A Technologic Analysis.

Purpose: The purpose of this technologic analysis was to review use of ionic silver as a component of topical wound therapy products.

Approach: Published literature from a variety of fields related to ionic silver and its use in topical wound therapy products was reviewed and a summary of common commercially available wound care products containing ionic silver was generated, along with general recommendations for use. Safety information from both manufacturer guidelines and the Manufacturer and User Facility Device Experience (MAUDE) database is summarized.

Conclusions: Various formulations of ionic silver products are used for topical treatment of wounds. Antimicrobial activity varies according to the specific silver formulation and type of microorganisms in the wound bed. In vitro evidence suggests that some bacterial strains may be developing resistance to ionic silver. Improved knowledge of the benefits and safety precautions associated with topical silver preparations can guide its application to topical therapy for wound healing.