AI Article Synopsis
- The study examines the role of JKAP in T-cell responses and inflammation in acute ischemic stroke (AIS) patients, particularly focusing on T-helper 1 (Th1) and T-helper 17 (Th17) cell levels.
- In 155 AIS patients, findings showed lower JKAP levels, higher Th17 cells, and a negative correlation between JKAP and both Th1/Th17 cells and inflammatory markers.
- Results suggest that higher JKAP levels may be associated with milder disease severity and potential benefits in recurrence-free survival among AIS patients.
Article Abstract
Objective: JKAP modifies T-cell immune response and inflammation, also involves in cardia-cerebrovascular disease etiology. This study intended to explore JKAP's relation with T-helper 1 (Th1), T-helper 17 (Th17) cell levels, clinical properties, and recurrence-free survival (RFS) in acute ischemic stroke (AIS) patients.
Methods: A total of 155 AIS patients were analyzed. Serum JKAP, interferon-gamma (IFN-γ), and interleukin-17A (IL-17A) were detected by ELISA; then blood Th1 and Th17 cells were quantified by flow cytometry. Besides, 30 healthy subjects were enrolled as controls to detect JKAP, Th1, and Th17 cells.
Results: JKAP level was lower (p < 0.001), Th1 cells were not differed (p = 0.068), but Th17 cells were elevated in AIS patients versus controls (p < 0.001). Meanwhile, JKAP was negatively correlated with Th1 cells (p = 0.038), Th17 cells (P<0.001), IFN-γ (p = 0.002), and IL-17A (p < 0.001) in AIS patients. JKAP was negatively associated with the National Institutes of Health Stroke Scale (NIHSS) score (p < 0.001), but Th17 cells (p = 0.001), IFN-γ (p = 0.035), and IL-17A (p = 0.008) levels were positively associated with NIHSS score. Additionally, accumulating RFS was numerically longer in patients with JKAP Quantile (Q) 4 than patients with JKAP Q1-Q3 (p = 0.068), and numerically better in patients with JKAP Q3-Q4 than patients with JKAP Q1-Q2 (p = 0.069), but without statistical significance.
Conclusion: JKAP correlates with lower Th1 and Th17 cell percentages as well as milder disease severity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396169 | PMC |
| http://dx.doi.org/10.1002/jcla.24535 | DOI Listing |
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