AI Article Synopsis
- The study investigates how stretch and frequent beating (tachycardia) affect early changes in human heart tissue, specifically in the atria.
- Researchers applied isometric stretch and sustained tachycardia to human atrial muscle samples for 6 hours and analyzed gene expression, discovering that miR-1183 was significantly up-regulated.
- Findings suggest that despite different effects on gene expression patterns, both cardiac stressors lead to increased levels of miR-1183, indicating its potential as a biomarker for heart tissue changes in diseases like atrial fibrillation.
Article Abstract
Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes and . Furthermore, miR-1183 was also significantly up-regulated in chronically remodeled atrial samples from patients with persistent atrial fibrillation (3-fold up-regulation versus sinus rhythm samples), and in ventricular myocardium from dilative cardiomyopathy hearts (2-fold up-regulation) as compared to non-failing controls. In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266684 | PMC |
| http://dx.doi.org/10.3390/ijms23136962 | DOI Listing |
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